Powder: -20°C for 3 years | In solvent: -80°C for 1 year
T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2).
説明 | T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2). |
ターゲット&IC50 | SGLT1 (human):22.8 μM (IC50), SGLT2 (human):2.3 μM (IC50) |
In vivo | Administration of 0.03% and 0.1% (wt/wt diet) T-1095 to STZ rats for 4 weeks improved the hyperglycemia and dose-dependently decreased HbA1c[1]. Moreover, treatment with 0.1% (wt/wt diet) T-1095 in STZ rats for 8 weeks not only reduced blood glucose and HbA1c, levels but also prevented the elevation of urinary albumin levels and kidney weight and the development of epithelial vacuolation[1]. The expression of renal SGLT2, a major glucose transporter in the kidney, was not different in normal, STZ, and T-1095-treated STZ rats. In contrast, the elevated renal GLUT2 level in STZ rats was suppressed by T-1095[1]. |
分子量 | 516.49 |
分子式 | C26H28O11 |
CAS No. | 209746-59-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (116.17 mM)
You can also refer to dose conversion for different animals. 詳細
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T-1095 209746-59-8 GPCR/G Protein Metabolism transporter SGLT SGLT1 Sodium-dependent glucose cotransporters antidiabetic SGLT2 Inhibitor orally active T1095 inhibit T 1095 inhibitor