Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 : 47 nM in a fluorescence anisotropy assay)
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 9,000 | |||
10 mg | 在庫あり | ¥ 16,500 | |||
25 mg | 在庫あり | ¥ 35,500 | |||
50 mg | 在庫あり | ¥ 62,500 | |||
100 mg | 在庫あり | ¥ 110,000 | |||
500 mg | 在庫あり | ¥ 241,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,000 |
説明 | LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 : 47 nM in a fluorescence anisotropy assay) |
ターゲット&IC50 | TrkB:47 nM |
In vitro | In vitro, LM22A-4 increases survival of hippocampal neurons via activation of TrkB as well as Akt and ERK downstream pro-survival signaling pathways[1]. |
In vivo | Treatment of Het mice with LM22A-4 for 4 weeks rescued wild-type levels of TrkB phosphorylation in the medulla and pons and restored wild-type breathing frequency[1]. |
動物実験 | Wt and Het littermates were divided into 4 groups: Wt vehicle-treated (100 μl of 0.9% NaCl, i.p., b.i.d.), Wt drug-treated (50 mg/kg LM22A-4 in 0.9% NaCl, i.p., b.i.d.), Het vehicle-treated (100 μl of 0.9% NaCl, i.p., b.i.d.), and Het drug-treated (50 mg/kg LM22A-4 in 0.9% NaCl, i.p., b.i.d.).?Each mouse was treated from 8 to 13 weeks of age.?Whole-body plethysmography was performed during week 12 and animals were subsequently killed and tissues harvested for TrkB Western blots and BDNF ELISA during week[1]. |
分子量 | 339.34 |
分子式 | C15H21N3O6 |
CAS No. | 37988-18-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (147.34 mM)
DMSO: 29 mg/mL (85.46 mM)
You can also refer to dose conversion for different animals. 詳細
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LM22A-4 37988-18-4 Tyrosine Kinase/Adaptors Trk receptor LM-22A-4 Inhibitor Trk Receptor inhibit LM22A4 Tropomyosin related kinase receptor LM22A 4 inhibitor