Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).
説明 | LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM). |
ターゲット&IC50 | p70 S6K:4 nM |
In vitro |
In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM[1]. Combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus, LY2584702 has significant synergistic effects [2]. |
In vivo |
LY2584702 (12.5 mg/kg BID), shows significant antitumor activity in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. [1] |
分子量 | 445.42 |
分子式 | C21H19F4N7 |
CAS No. | 1082949-67-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1 mg/mL(2.24 mM), Heating is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LY-2584702 free base 1082949-67-4 MAPK PI3K/Akt/mTOR signaling mTOR S6 Kinase Ribosomal S6 Kinase (RSK) S6K LY2584702 LY-2584702 Inhibitor inhibit LY2584702 free base LY 2584702 free base LY 2584702 inhibitor