Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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500 mg | 在庫あり | ¥ 10,500 | |||
1 g | 在庫あり | ¥ 14,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) |
In vitro | Lansoprazole significantly attenuates intestinal damage induced by ischemia-reperfusion or indomethacin. Exogenous administration of Lansoprazole can prevent injury to the small intestine caused by ischemia-reperfusion or indomethacin. Lansoprazole inhibits acute inflammatory responses and mucosal injury in rats subjected to ischemia-reperfusion or indomethacin-induced damage. |
In vivo | Lansoprazole is a potent antisecretory agent that inhibits gastric acid secretion by blocking the stomach's hydrogen/potassium adenosine triphosphatase (H+, K+-ATPase). It suppresses the upregulation of adhesion molecules in blood vessels, neutrophil activation, and the production of pro-inflammatory cytokines from activated endothelial cells. Furthermore, Lansoprazole induces the expression of various genes in gastric epithelial cells, including Phase II detoxifying enzymes (NADPH-quinone oxidoreductase, glutathione S-transferase) and antioxidative stress proteins (HO-1, thioredoxin reductase, and superoxide dismutase). In rat gastric epithelial cells, Lansoprazole upregulates HO-1 expression and exerts anti-inflammatory effects. |
別名 | A-65006, AG-1749 |
分子量 | 369.36 |
分子式 | C16H14F3N3O2S |
CAS No. | 103577-45-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1eq. HCl: 18.5 mg/mL (50 mM)
DMSO: 50 mg/mL (135.37 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Lansoprazole 103577-45-3 Membrane transporter/Ion channel Metabolism Microbiology/Virology Antibacterial Proton pump Phospholipase acid AG1749 N-SMase A65006 ELT TSTQ Bacterial inhibit exosome Proton Pump gastric HFD STZ A-65006 A 65006 AG-1749 AG 1749 Inhibitor inhibitor