Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.
説明 | MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs. |
ターゲット&IC50 | CDK1-CyclinB:138 nM (cell free), CDK5-p35:159 nM (cell free), CDK4-Cyclin D:112 nM (cell free), CDK5-p25:186 nM (cell free), CDK9-CyclinT1:5 nM (cell free) |
In vitro | MC180295 is a potent and selective CDK9-Cyclin T1 inhibitor, with an IC50 of 5 nM, at least 22-fold more selective for CDK9 over other CDKs, such as CDK1-Cyclin B (IC50, 138 nM), CDK2-Cyclin A (IC50, 233 nM), CDK2-Cyclin E (IC50, 367 nM), CDK3-Cyclin E (IC50, 399 nM), CDK4-Cyclin D (IC50, 112 nM), CDK5-P35 (IC50, 159 nM), CDK5-P25 (IC50, 186 nM). MC180295 (0.1 μM) demonstrates broad anti-cancer activity in vitro. |
In vivo | MC180295 (20 mg/kg, i.p., qod) inhibits significant anti-tumor activity in mice bearing SW48 cells while not inhibiting human T cell growth in vivo. |
別名 | (rel)-MC180295 |
分子量 | 358.41 |
分子式 | C17H18N4O3S |
CAS No. | 2237942-08-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 70 mg/mL (195.31 mM )
You can also refer to dose conversion for different animals. 詳細
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MC180295 2237942-08-2 Cell Cycle/Checkpoint CDK (rel)-MC-180295 Cyclin dependent kinase (rel)-MC180295 (rel)-MC 180295 inhibit MC-180295 Inhibitor MC 180295 inhibitor