Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.
ターゲット&IC50 | Ca2+ flux:196 ± 30 nM((IMR-32 cells)), MCH1R:65 nM , ERG (human):4.0 nM(IMR-32 cells) |
In vitro | MCHR1 antagonist 2 has inhibitory effects on Ca2+ flux, and hERG, with IC50s of 196 ± 30 nM and 4.0 ± 0.8 nM, respectively, in IMR-32 cells.MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM. |
分子量 | 424.42 |
分子式 | C23H21FN2O5 |
CAS No. | 863115-70-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9 mg/mL (21.21 mM), when pH is adjusted to 6 with HCl. Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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MCHR1 antagonist 2 863115-70-2 Angiogenesis GPCR/G Protein JAK/STAT signaling Tyrosine Kinase/Adaptors HER Melanin-concentrating Hormone Receptor (MCHR) inhibit Potassium Channel IMR-32 melanin hormone Melanin concentrating hormone receptor 1 MCHR-1 antagonist 2 hERG concentrating MCHR1 (GPR24) Inhibitor KcsA inhibitor