Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML-335 is a μ-δ isomer-targeted agonist, a μOR-δOR-biased ligand that can serve as a scaffold for the development of unique types of (isomer-biased) drugs.ML-335 is a MOR (μ-opioid receptor)/DOR (δ-opioid receptor) heterodimer, with anti-injury sensory activity and pain inhibitory activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 21,500 | |||
10 mg | 在庫あり | ¥ 34,000 | |||
25 mg | 在庫あり | ¥ 66,500 | |||
50 mg | 在庫あり | ¥ 106,500 | |||
100 mg | 在庫あり | ¥ 153,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | ML-335 is a μ-δ isomer-targeted agonist, a μOR-δOR-biased ligand that can serve as a scaffold for the development of unique types of (isomer-biased) drugs.ML-335 is a MOR (μ-opioid receptor)/DOR (δ-opioid receptor) heterodimer, with anti-injury sensory activity and pain inhibitory activity. |
ターゲット&IC50 | μ opioid receptor:0.125 µM(EC50) |
In vivo | CYM51010 (ML-335) (subcutaneous injection; SNL rats) inhibited mechanical hypersensitivity in a dose-related manner (EC50: 1.09 mg/kg) and also reversed heat hyperalgesia and attenuated ongoing pain (2 mg/kg, subcutaneously)[1]. |
分子量 | 408.53 |
分子式 | C25H32N2O3 |
CAS No. | 1069498-96-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9.0 mg/mL (22.1 mM)
You can also refer to dose conversion for different animals. 詳細
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ML-335 1069498-96-9 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor ML335 ML 335 Inhibitor inhibitor inhibit