Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Medetomidine hydrochloride (MPV785) is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.
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10 mg | 在庫あり | ¥ 11,000 | |||
25 mg | 在庫あり | ¥ 19,000 | |||
50 mg | 在庫あり | ¥ 34,500 | |||
100 mg | 在庫あり | ¥ 45,000 | |||
200 mg | 在庫あり | ¥ 58,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Medetomidine hydrochloride (MPV785) is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor. |
ターゲット&IC50 | α2-adrenoceptor:1.08 nM(Ki) |
In vitro | Medetomidine is a selectiveα2-adrenoceptor agonist, with Ki of 1.08 nM, exhibits 1620-fold selectivity over α1-adrenoceptor, has very weak or no binding to other neurotransmitter receptors. [1] |
In vivo | In anesthetized rats, medetomidine (1-100 μg/kg, i.v.) induces a dose-dependent, relatively short-lived reduction in blood pressure and heart rate. In the pithed rat, medetomidine shows very potent vasopressor (PD50 1.7 μg/kg) and sympatho-inhibitory (ID50 1.6 μg/kg) effects without affecting basal heart rate. [2] Medetomidine induces dose-dependent sedation, which at high doses (>100μg/kg) includes loss of the righting reflex and hypothermia. Medetomidine induces a decreases in the turnover rate of biogenic amines in the brain, dose-dependently inhibits norepinephrine (NE) turnover, inhibits brain dopamine turnover at high doses, decreases serotonin turnover. [3] |
別名 | MPV785, Medetomidine HCl, Domitor |
分子量 | 236.74 |
分子式 | C13H16N2·HCl |
CAS No. | 86347-15-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (253.44 mM)
H2O: 23.7 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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Medetomidine hydrochloride 86347-15-1 GPCR/G Protein Neuroscience Adrenergic Receptor anxiolysis inhibit sedation Medetomidine α2-adrenoceptor peripheral nervous system analgesia MPV 785 central nervous system Inhibitor Medetomidine Hydrochloride MPV785 muscle relaxation Beta Receptor MPV-785 Medetomidine HCl Domitor inhibitor