37
4
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T2524 | Dexmedetomidine | Adrenergic Receptor | |
Dexmedetomidine is a Central alpha-2 Adrenergic Agonist. The mechanism of action of dexmedetomidine is as an Adrenergic alpha2-Agonist. The physiologic effect of dexmedetomidine is by means of General Anesthesia. | |||
T6554 | JZL 184 | JZL184 | Lipase |
JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively. | |||
T21422 | Methylnaltrexone bromide | Relistor,MOA-728,MOA 728,Methylnaltrexone,MOA728 | Opioid Receptor |
Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists. Methylnaltrexone bromide acts to reverse some of the side effects of opioid drugs such as constipation without af... | |||
T1780 | Parecoxib | SC 69124,Vorth-P,Valus-P | COX |
Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor. | |||
T6579 | Medetomidine hydrochloride | MPV785,Medetomidine HCl,Domitor | Adrenergic Receptor |
Medetomidine hydrochloride (MPV785) is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor. | |||
T6466 | Dexmedetomidine hydrochloride | Precedex,(+)-Medetomidine hydrochloride,(S)-Medetomidine hydrochloride,Dexmedetomidine HCl | Adrenergic Receptor |
Dexmedetomidine hydrochloride (Precedex) is an imidazole derivative that is an agonist of the adrenergic alpha-2 receptor. It is closely-related to MEDETOMIDINE, which is the racemic form of this compound. | |||
T0954 | Halothane | Narcotane,Anestan | Potassium Channel , Chloride channel , GABA Receptor , NMDAR |
Halothane (Anestan) is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly.... | |||
T20172L | Kyotorphin acetate | Endogenous Metabolite , Antibacterial | |
Kyotorphin acetate is an endogenous peptide with analgesia activity and can be used as a biomarker of Alzheimer disease. | |||
T50082 | Org 25543 | Chloride channel | |
Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain. | |||
T6504 | Flupirtine maleate | Katadolon maleate | Potassium Channel , NMDAR , iGluR |
Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal potassium channel opener. | |||
T0056 | Oxeladin citrate | Others | |
Oxeladin citrate is a highly potent and effective cough suppressant, which can treat all types of cough of various etiologies. It is not related to opium or its derivatives, so treatment with oxeladin is no risk of add... | |||
T1787 | Levobupivacaine | Sodium Channel | |
Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZ... | |||
T31541 | D-Kyotorphin | H-L-Tyr-D-Arg-OH | |
D-Kyotorphin is a synthetic neuropeptide kyotorphin analog that produces naloxone reversible analgesia. | |||
T34152L | Propiomazine HCl | Propiomazine hydrochloride,Largon | |
Propiomazine HCl is an analgesia adjunct. | |||
T27888 | LY 190388 | LY190388,LY-190388 | |
LY 190388 is a penicillamine-containing enkephalin analog used as an mu receptor agonist with analgesia activity. | |||
T70078 | Fadolmidine | ||
Fadolmidine is a novel and potent alpha2 -adrenoceptor (alpha2) -AR) agonist developed for spinal analgesia. | |||
T32105 | Cipepofol | HSK3486,HSK 3486,HSK-3486 | |
HSK3486 is similar to propofol and is a general anesthetic, which may have therapeutic potential in insomnia, migraine, anxiety, analgesia, and other aspects. | |||
T25675 | Leucinal | L-Leucinal | |
Leucinal inhibits the activity of brain aminopeptidase and potentiates analgesia induced by leu-enkephalen. | |||
T12970L | Solabegron HCl | GW-427,353,GW427353,GW-427353,GW 427,353,GW427,353 | |
Solabegron (GW-427,353), is a selective agonist of β3 adrenergic receptors. In addition, Solabegron has been shown to produce visceral analgesia by releasing somatostatin from fat cells. | |||
T31190 | Dafphedyn | ||
Dafphedyn, [D-Ala2, (F5) Phe4]-dynorphin 1-13-NH2 (DAFPHEDYN) is an effective analog of strong endorphin 1-13 and produces diuretic and deep analgesia when administered intravenously in rats. | |||
T68959 | Fenobam hydrate | ||
Fenobam hydrate is a noncompetitive antagonist and inverse agonist of metabotropic glutamate receptor 5 (mGluR5). It inhibits intracellular calcium mobilization induced by the glutamate analog quisqualate and inhibits ba... | |||
T80518 | Mambalgin-3 | Sodium Channel | |
Mambalgin-3, an acid-sensitive ion channel 1 (ASIC1) inhibitor, has potential applications in analgesia research [1]. | |||
T76186 | Tyr-W-MIF-1 | ||
Tyr-W-MIF-1, an opioid tetrapeptide, exhibits both opiate and antiopiate activities, and has been demonstrated to induce analgesia [1] [2] [5]. | |||
T11038 | Dibutyryl-cGMP sodium | Bt2cGMP sodium | Others |
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analog. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits [3H]-arachidonic acid release in ... | |||
T28845 | SR142948A HCl | SR142948A,SR 142948A,SR-142948A,SR142948A hydrochloride | |
SR 142948A is a non-peptide antagonist of neurotensin receptor. SR 142948A affects the expression of c-Fos and has properties of antipsychotic agent. SR 142948A blocks hypothermia and analgesia induced by neurotensin. It... | |||
TP1958 | PL-017 | PL 017 | |
Selective μ opioid receptor agonist (IC50 values are 5.5 and > 10000 nM for inhibition of 125I-FK 33,824 and 125I-DADLE binding to μ and δ sites respectively). Produces naloxone-reversible analgesia, catalepsy and hypert... | |||
T80515 | β-Endorphin (1-27) (human) | Opioid Receptor | |
β-Endorphin (1-27) (human) is an opioid antagonist that selectively binds to μ-, δ-, and κ-opioid receptors, with dissociation constants (Kis) of 5.31, 6.17, and 39.82 nM, respectively. It inhibits analgesia induced by b... | |||
T75840 | Hemokinin 1, human TFA | ||
Hemokinin 1, human TFA acts as a selective full agonist at the tachykinin neurokinin 1 (NK1) receptor, while also being a full agonist at NK2 and NK3 receptors. It is capable of inducing opioid-independent analgesia [1] ... | |||
T37670 | CAY10568 | ||
Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, w... | |||
T75919 | PL-017 TFA | ||
PL-017 TFA, a potent and selective μ-opioid receptor agonist, displays significant affinity with an IC50 of 5.5 nM for 125I-FK 33,824 binding to the μ-site. This compound is effective in producing long-lasting, reversibl... | |||
T81763 | MOR agonist-3 | ||
MOR agonist-3 (Compound 84) is a dual D3R/MOR antagonist with K i values of 382 nM and 55.2 nM, respectively. It shows promise for analgesia via partial agonism at MORs and may mitigate opioid abuse via D3R antagonism. T... | |||
T61475 | Ropivacaine mesylate | ||
Ropivacaine mesylate, a long-acting amide local anaesthetic, is used for spinal block and effectively mitigates neuropathic pain. It achieves analgesia by reversibly inhibiting sodium ion influx in nerve fibers, thus blo... | |||
T37374 | URB754 | ||
URB754 is a potent and noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 200 nM for the recombinant rat brain enzyme. However, it does not inhibit human recombinant, rat brain, or mo... | |||
T73677 | SR 142948 dihydrochloride | ||
SR 142948 dihydrochloride is a selective, orally active, non-peptide neurotensin receptor (NT) antagonist, featuring IC50 values of 1.19 nM, 0.32 nM, and 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, res... | |||
T70077 | Fadolmidine HCl | ||
Fadolmidine, also known as MPV-2426, is a novel and potent alpha2 -adrenoceptor (alpha2) -AR) agonist developed for spinal analgesia. Fadolmidine displayed high affinity and full agonist efficacy at all three human alpha... | |||
T37391 | PSEM 308 hydrochloride | ||
PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neuro... | |||
T36722 | Deltorphin II (trifluoroacetate salt) | ||
Deltorphin II is a peptide agonist of δ2-opioid receptors.1,2It is selective for δ-opioid receptors over μ- and κ-opioid receptors in radioligand bindings assays (Kis = 0.0033, >1, and >1 μM, respectively) and induces [3... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T5691 | Paulownin | Anti-infection | |
Paulownin, a furofuran lignan from Paulownia tomentosa,has the action of anti-inflammation,analgesia,immunity,hypoglycemia and has little toxicity. | |||
T5734 | (+)-BORNEOL | d-Borneol | GABA Receptor |
(+)-BORNEOL (d-Borneol) is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM. | |||
T3834 | 8-Epideoxyloganic acid | ROS , Immunology/Inflammation related | |
8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibl... | |||
TN3778 | De-4'-O-methylyangambin | Antifection | |
De-4'-O-methylyangambin exhibits antibacterial effects. It also has analgesia activity. |