Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
50 mg | 在庫あり | ¥ 12,000 | |||
100 mg | 在庫あり | ¥ 18,000 | |||
500 mg | 在庫あり | ¥ 51,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,500 |
説明 | Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials. |
ターゲット&IC50 | HMG-CoA reductase:1 nM(ki) |
In vitro | Mevastatin competitively inhibits HMG-CoA reductase, subsequently reducing cholesterol synthesis in the liver. After 14 days of high-dose treatment, a more than 30% increase in baseline absolute cerebral blood flow was observed. Oral administration of Mevastatin at doses of 5 mg/kg and 20 mg/kg led to reductions in serum cholesterol levels 3 hours post-administration, with the 20 mg/kg dosage decreasing serum cholesterol by approximately 30%. |
In vivo | The bicyclic portion of Mevastatin binds to the active site of coenzyme A. Mevastatin elevates eNOS mRNA and protein levels, reduces infarct size, and ameliorates neurological deficits in a dose- and time-dependent manner. At a concentration of 0.01 pg/mL (26 nM), Mevastatin can reduce cholesterol synthesis by 50% compared with the control group. |
別名 | Compactin, ML236B |
分子量 | 390.51 |
分子式 | C23H34O5 |
CAS No. | 73573-88-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 72 mg/mL (184.4 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Mevastatin 73573-88-3 Apoptosis Autophagy Metabolism Microbiology/Virology Lipid HMG-CoA Reductase Antibiotic Antibacterial BMP-2 Compactin cardiovascular inhibit phosphorylation lipid-lowering neuroprotection EGFR NF-κB Statins ML236B Bacterial RANKL HMG-CoA Reductase (HMGCR) eNOS Inhibitor inhibitor