Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
説明 | Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation. |
In vitro | Mito-LND inhibits cell growth of H2030BrM3 and A549 cells with IC50 of 0.74 μM and 0.69?μM, respectively. Mito-LND inhibits mitochondrial complex I and II activities with IC50 of 1.2 μM and 2.4?μM, respectively in H2030BrM3 cells. Mito-LND potently induces mitochondrial ROS generation in H2030BrM3 lung cancer cells. Mito-LND decreases the levels of phosphorylated AKT. Mito-LND also decreases the phosphorylation of P70S6K and other energy-sensing proteins in both the parental and metastatic lung cancer cell lines, indicating that Mito-LND specifically downregulates mTOR signaling. |
In vivo | Mito-LNDtreatment markedly enhanced potency against both lung cancer progression and metastasis. Mito-LND also decreases the rate of growth of A549 tumor xenografts. Mito-LND treatment shows a marked decrease in lung cancer brain metastasis in NOD/SCID mice bearing H2030BrM3 cells. |
別名 | Mito-Loidamine |
分子量 | 801.62 |
分子式 | C43H45BrCl2N3OP |
CAS No. | 2361564-49-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL(56.14 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Mito-LND 2361564-49-8 Apoptosis Autophagy Immunology/Inflammation Metabolism NF-Κb Mitochondrial Metabolism OXPHOS Reactive Oxygen Species Mito-Lonidamine mTOR Mito-Loidamine p70S6K oxidative MitoLND Inhibitor inhibit mitochondria Mito LND anti-invasive anti-cancer phosphorylation AKT inhibitor