Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 11,000 | |||
10 mg | 在庫あり | ¥ 18,000 | |||
25 mg | 在庫あり | ¥ 36,500 | |||
50 mg | 在庫あり | ¥ 60,500 | |||
100 mg | 在庫あり | ¥ 103,500 |
説明 | VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells. |
In vitro | VLX600 as a drug that is preferentially active against quiescent cells in colon cancer 3-D microtissues.?The anticancer activity is associated with reduced mitochondrial respiration, leading to bioenergetic catastrophe and tumour cell death.?VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation.?Importantly, VLX600 displays tumour growth inhibition in vivo. |
細胞研究 | HCT116, HT29, SW620, HT8, DLD and RKO cells.Concentration,0.1, 1, 10, 100μM. 72 hours |
分子量 | 317.35 |
分子式 | C17H15N7 |
CAS No. | 327031-55-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 8 mg/ml(25.21 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
VLX600 327031-55-0 Apoptosis Autophagy Metabolism OXPHOS Mitochondrial Metabolism iron VLX 600 HCT116 glycolytic colon chelator cancer proliferation Inhibitor oxidative phosphorylation VLX-600 inhibit inhibitor