Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.
説明 | EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells. |
ターゲット&IC50 | EGFR:21 nM (cell free), EGFR (L858R):63 nM (cell free), EGFR (L861Q):4 nM (cell free) |
In vitro | EGFR Inhibitor possesses an enzymatic IC50= 21 nM against EGFR kinase in vitro and blocks receptor autophosphorylation in cells. EGFR Inhibitor also potently inhibits two EGFR mutants associated with clinical response to gefitinib: L858R (IC50: 63 nM) and L861Q (IC50: 4 nM), but displays much weaker activity against Her 4 (IC50: 7640 nM). |
別名 | EGFR Inhibitor |
分子量 | 413.4 |
分子式 | C21H18F3N5O |
CAS No. | 879127-07-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 10 mg/mL
DMSO: 50 mg/mL (120.95 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
EGFR-IN-12 879127-07-8 Angiogenesis Apoptosis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR EGFRIN12 autophosphorylation anti-proliferation 4,6-disubstituted antitumor kinases Epidermal growth factor receptor EGFR Inhibitor inhibit EGFR IN 12 AKT pyrimidine ErbB-1 Inhibitor HER1 Tyrosine inhibitor