Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.
説明 | NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity. |
In vitro | NDMC101 markedly inhibited RANKL-induced formation of TRAP+ multinucleated cells in RAW264.7 and bone marrow macrophage cells (BMMs).?Moreover, pit formation assay showed that NDMC101 significantly reduced the bone-resorbing activity of mature osteoclasts[1]. |
In vivo | In CIA mice, oral administration of NDMC101 reduced arthritic index and mitigated bone erosion.?Serum TNF-α and IL-1β concentrations in these mice were decreased significantly at the higher dose of 62.5 mg/kg[1]. |
細胞研究 | Differentiation into osteoclast-like cells was examined by tartrate-resistant acid phosphatase (TRAP) staining and expression of osteoclast differentiation markers[1]. |
動物実験 | Collagen-induced arthritis (CIA) mice were administered test articles by gavages to assess its efficacy.?Then clinical, histological, and biochemical parameters were assessed to determine the effects of N-(4-chloro-2-fluorophenyl)-2-hydroxybenzamide (NDMC101) on synovial inflammation and bone erosion by hematoxlin and eosin staining and Enzyme-linked immunosorbent assay (ELISA)[1]. |
分子量 | 265.67 |
分子式 | C13H9ClFNO2 |
CAS No. | 1308631-40-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (41.4 mM)
You can also refer to dose conversion for different animals. 詳細
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NDMC101 1308631-40-4 NF-Κb Others Proteases/Proteasome Ubiquitination NF-κB Proteasome rheumatoid arthritis inhibit RAW 264.7 NDMC-101 NSAID NDMC 101 Bone Inhibitor Nuclear factor-κB DPP bone destruction osteoblast marrow-derived macrophages synovial inflammation Nuclear factor-kappaB Dipeptidyl Peptidase inhibitor