Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup-presses NF-κB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect
説明 | GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup-presses NF-κB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect |
ターゲット&IC50 | IκBα phosphorylation:5.2 μM |
別名 | GS-143, GS 143 |
分子量 | 466.46 |
分子式 | C28H19FN2O4 |
CAS No. | 916232-21-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (85.75 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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GS143 916232-21-8 NF-Κb Ubiquitination IκB/IKK E1/E2/E3 Enzyme NF-κB E2 conjugating enzyme inhibit IκBα Th2 Ubiquitin conjugating enzyme Ubiquitin ligase IL-4 IκB kinase βTrCP1 Nuclear factor-kappaB eosinophil Ubiquitin activating enzyme Nuclear factor-κB I kappa B kinase E3 ligating enzyme GS-143 IKK E1 activating enzyme anti-asthma ubiquitination Inhibitor airway GS 143 inflammation inhibitor