|
T2553 |
Etofenamate
|
|
COX
|
|
Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain. |
|
T2550 |
Tolmetin
|
Tolectin |
COX
|
|
Tolmetin (Tolectin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of tolmetin is as a Cyclooxygenase Inhibitor. The chemical classification of tolmetin is Nonsteroidal Anti-inflammatory Compounds. |
|
T1432 |
Phenylbutazone
|
Butazolidine |
COX
|
|
Phenylbutazone (Butazolidine) is a butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ankylosing spondylitis, rheumatoid arthritis, and reactive arthri... |
|
T5460 |
Mofezolac
|
|
COX
|
|
Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000 |
|
T10152 |
4-Methylamino antipyrine
|
|
COX
,
Drug Metabolite
|
|
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methylamino antipyrine has analgesic, antipyretic, and relativel... |
|
T0291 |
Flurbiprofen
|
dl-Flurbiprofen |
Apoptosis
,
COX
,
MRP
|
|
Flurbiprofen (dl-Flurbiprofen) is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE. |
|
T0159 |
Pranoprofen
|
Pyranoprofen |
Apoptosis
,
COX
,
PGE Synthase
,
Prostaglandin Receptor
|
|
Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology. |
|
T0463 |
Loxoprofen
|
Loxoprofene,Loxoprofeno,Koloxo |
COX
|
|
Loxoprofen (Koloxo) is an anti-inflammatory non-steroidal medicine. |
|
T6737 |
Zaltoprofen
|
CN100,Soleton |
COX
|
|
Zaltoprofen (Soleton) is a Cox-1 and Cox-2 inhibitor, which is used for the treatment of arthritis. |
|
T8550 |
NDMC101
|
|
Others
,
NF-κB
,
Proteasome
|
|
NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity. |
|
T27635 |
Isoxepac
|
Olopatadine USP Related Compound C |
Others
|
|
Isoxepac (Olopatadine USP Related Compound C) is a non-steroidal anti-antiphlogistic agent and analgesic. |
|
T9042 |
Teriflunomide impurity 3
|
4-Amino-N-(4-trifluoromethylphenyl)benzamide |
COX
|
|
Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor(IC50 of 30 μM). It is less active against COX-2 (IC50>100 μM). |
|
T21294 |
Polmacoxib
|
CG-100649,CG100649,CG 100649 |
COX
,
Carbonic Anhydrase
|
|
Polmacoxib (CG 100649) is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant colorectal lesions in mouse models, partly through... |
|
T0708 |
Oxaprozin
|
Oxaprozinum,Wy21743 |
NF-κB
,
COX
|
|
Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compound... |
|
T21412 |
Ketorolac
|
Toradol,Sprix,Acuvail,Macril,Acular |
COX
|
|
Ketorolac (Acuvail) is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives. It acts by inhibiting the bodily synthesis of prostaglandins. |
|
T36683 |
Vedaprofen
|
Quadrisol,PM 150,CERM 10202 |
COX
,
Antibacterial
,
Prostaglandin Receptor
|
|
Vedaprofen (PM 150) inhibits COX-1 and reduces prostaglandin H2 synthesis with anti-inflammatory activities. Vedaprofen is an inhibitor of Escherichia coli sliding clamp with the IC50 of 222 μM and Ki of 131 μM. |
|
T0459 |
Sulindac
|
Arthrocine,MK-231,Clinoril,Sulindac sulfoxide |
COX
,
Autophagy
|
|
Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl... |
|
T22307 |
Diclofenac Epolamine
|
diclofenac hydroxyethylpyrrolidine,DHEP,DIEP |
Others
|
|
Diclofenac Epolamine (DHEP) is a non-steroidal anti-inflammatory agent (NSAID) with analgesic and antipyretic actions. |
|
T6498 |
Fenoprofen calcium hydrate
|
Feprona dihydrate,Fenoprofen calcium salt dihydrate,Progesic dihydrate |
Apoptosis
,
Others
,
COX
|
|
Fenoprofen calcium hydrate (Progesic dihydrate) is a non-steroidal anti-inflammatory drug (NSAID). |
|
T19672 |
Amtolmetin guacil
|
MED 15,MED15,ST679,ST-679,ST 679,MED-15 |
COX
|
|
Amtolmetin guacil (ST-679) inhibits prostaglandin synthesis and cyclooxygenase. Amtolmetin guacil has similar NSAID properties like tolmetin with additional analgesic, antipyretic, and gastroprotective properties. |
|
T10355 |
Apyramide
|
|
COX
|
|
Apyramide is an anti-inflammatory agent (NSAID) and behaves as a prodrug of indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2. |
|
T11340 |
Furprofen
|
|
Prostaglandin Receptor
|
|
Furprofen, a non-steroidal anti-inflammatory drug (NSAID), exerts its effects by inhibiting the synthesis of prostaglandin (PGE). This compound demonstrates analgesic properties and can be conveniently administered orall... |
|
T37482 |
Diclofenac methyl ester
|
|
Others
|
|
Diclofenac methyl ester is a hydrophobic prodrug form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac . It is more soluble than diclofenac acid in isopropylmyristate. Diclofenac methyl ester does not perme... |
|
T4542 |
Clonixin
|
Clonixic acid |
Others
|
|
Clonixin (Clonixic acid) is a non-steroidal anti-inflammatory drug (NSAID) with analgesic properties. This compound has been reported to block prostaglandin synthesis, and to block inward calcium currents. |
|
T0448 |
(S)-(+)-Ibuprofen
|
Dexibuprofen,(S)-Ibuprofen |
BCL
,
Thrombin
,
Cysteine Protease
,
COX
,
PPAR
|
|
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX). |
|
T1394 |
Ibuprofen
|
Brufen,(±)-Ibuprofe,Motrin,Advil |
COX
|
|
Ibuprofen (Advil) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resu... |
|
T1421 |
Aceclofenac
|
Preservex,Airtal |
COX
|
|
Aceclofenac (Preservex) is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties. |
|
T22437 |
Tazofelone
|
LY-213829 |
Others
|
|
Tazofelone (LY-213829) is a NSAID used for the treatment of inflammatory bowel disease. |
|
T0055 |
Glafenine
|
Glafenin |
COX
|
|
Glafenine (Glafenin), a non-narcotic analgesic agent, is a non-steroidal anti-inflammatory drug (NSAID), and widely used for the therapy of pains of various origins. |
|
T7363 |
Ibuprofen Piconol
|
U75630 |
Others
|
|
Ibuprofen Piconol (U75630) is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns.Ibuprofen piconol is a Pyridyl ester of ibuprofen. |
|
T7207 |
FK 3311
|
FK-3311,COX-2 Inhibitor V |
COX
|
|
FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID) |
|
T1574 |
Etoricoxib
|
Arcoxia,MK-663,Tauxib,L-791456,Nucoxia,Desvenlafaxine |
COX
|
|
Etoricoxib (MK-663) is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenas... |
|
T1582 |
Naproxen
|
(S)-Naproxen |
COX
,
Autophagy
|
|
Naproxen ((S)-Naproxen) is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. |
|
T0432 |
Diclofenac diethylamine
|
|
Apoptosis
,
COX
|
|
Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID). |
|
T1325 |
Carprofen
|
Ridamyl,Imadyl,Rimadyl |
FAAH
,
COX
,
Autophagy
|
|
Carprofen (Ridamyl) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. |
|
T4545 |
Propacetamol Hydrochloride
|
Propacetamol HCL |
Others
|
|
Propacetamol Hydrochloride (Propacetamol HCL) is a prodrug of paracetamol (acetaminophen) with improved water solubility. Propacetamol Hydrochloride is an analgesic drug delivered by IV when the oral application of NSAID... |
|
T7882 |
Indomethacin farnesil
|
Infree |
Others
,
COX
,
Autophagy
|
|
Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug (DMARD). |
|
T0498 |
Salsalate
|
Disalicylic acid,Salicylsalicylic acid,Sasapyrine,NSC-49171 |
Reactive Oxygen Species
,
COX
|
|
Salsalate (Sasapyrine) is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities. |
|
T1002 |
Etodolac
|
Ultradol,AY-24236,Etodolic acid,Lodine |
Retinoid Receptor
,
COX
|
|
Etodolac (AY-24236) inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, and inflammation. Etodolac is a pyranocarboxylic ... |
|
T6424 |
Bromfenac Sodium
|
AHR 10282B,Bronuck,AHR 10282R |
COX
|
|
Bromfenac Sodium (AHR 10282R) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2. |
|
T1555 |
Diclofenac sodium
|
GP 45840 |
Apoptosis
,
COX
|
|
Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt. |
|
T0219 |
Valdecoxib
|
SC 65872 |
COX
|
|
Valdecoxib (SC 65872) is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classified as a nonsteroidal anti-inflammatory drug, or N... |
|
T68155 |
Tebufelone
|
|
Prostaglandin Receptor
,
LTR
|
|
Tebufelone is a potent in vitro inhibitor of CO , a novel non-steroidal anti-inflammatory drug (NSAID) belonging to the di-tert-butylphenol (DTBP) class that has shown potent anti-inflammatory, analgesic and anti-reticul... |
|
T0839 |
Ketoprofen
|
RP-19583 |
Apoptosis
,
COX
,
MRP
|
|
Ketoprofen (RP-19583) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenas... |
|
T2403 |
Bromfenac sodium hydrate
|
Bromfenac sodium,Bromfenac monosodium salt sesquihydrate |
COX
|
|
Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic admi... |
|
T70843 |
Orazipone
|
|
|
|
Orazipone inhibits cytokine production and histamine release; an NSAID. |
|
T20869 |
Flunixin
|
Sch14714,Flunixinum,Flunixine,Sch 14714,Flunixino,Sch-14714 |
|
|
Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), antipyretic, and analgesic used in pigs, horses, and cattle. |
|
T7710L |
Mofebutazone sodium
|
BRN0213056,BRN 0213056,BRN-0213056 |
|
|
Mofebutazone sodium is, a nonsteroidal antiinflammatory drug (NSAID), is used to treat joint and muscular pain. |
|
T40461 |
Ibuprofen alcohol
|
|
|
|
Ibuprofen alcohol, a nonsteroidal antiinflammatory drug (NSAID), exhibits very little activity for acid-sensing ion channels (ASICs). |
|
T31817 |
Flumizole
|
CP-22665,Flumizol,UNII-Y4YQF944N9,Flumizole (USAN/INN),Flumizolum |
|
|
Flumizole is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclocxygenase (COX). |
