Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 37,500 | |||
5 mg | 在庫あり | ¥ 95,000 | |||
10 mg | 在庫あり | ¥ 142,000 | |||
25 mg | 在庫あり | ¥ 226,000 | |||
50 mg | 在庫あり | ¥ 305,500 | |||
100 mg | 在庫あり | ¥ 411,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 104,500 |
説明 | NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM). |
In vitro | NIK SMI1 inhibits the expression of NIK SMI1 response element regulated firefly luciferase reporter gene in HEK293 cells (IC50: 34±6 nM). NIK SMI1 inhibits BAFF-induced B cell (mouse) survival in vitro with an IC50 of 373±64 nM. Consistent with expectations for a NIK inhibitor, NIK SMI1 is shown to inhibit nuclear translocation of p52 (RelB) (IC50=70 nM). |
In vivo | The pharmacology of NIK SMI1 is examined in SD rat, CD-1 mouse, beagle, and cynomologous monkey with 20, 32, 18, and 7.8 mL/kg per min, respectively. The volume of distribution (Vd, L/kg) is 1.35, 1.58, 0.778, and 1.39, respectively. C57BL/6 mice are treated twice daily for 7 days with orally administered NIK SMI1 or with three injections of recombinant BAFF receptor fusion protein (Br3- mIgG2a) over the course of the 7-day experiment as a positive control . |
分子量 | 365.38 |
分子式 | C20H19N3O4 |
CAS No. | 1660114-31-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (273.69 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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NIK SMI1 1660114-31-7 NF-Κb NF-κB Nuclear factor-κB NIK SMI 1 Nuclear factor-kappaB inhibit Inhibitor NIK SMI-1 inhibitor