Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 21,000 | |||
5 mg | 在庫あり | ¥ 42,500 | |||
10 mg | 在庫あり | ¥ 61,000 | |||
25 mg | 在庫あり | ¥ 109,500 | |||
50 mg | 在庫あり | ¥ 156,500 | |||
100 mg | 在庫あり | ¥ 223,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 49,000 |
説明 | NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19). |
In vivo | NLX-204, displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein.?Preliminary in vivo studies confirmed its promising pharmacokinetic profile.?NLX-204 also robustly stimulated ERK1/2 phosphorylation in rat cortex and showed highly potent (MED = 0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test. |
分子量 | 409.13 |
分子式 | C20H23Cl2F2N3O2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (26.89 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NLX-204 hydrochloride(2170405-10-2 free base) GPCR/G Protein Neuroscience 5-HT Receptor 2170405-10-2 free base NLX-204 Hydrochloride NLX204 Hydrochloride NLX 204 hydrochloride(2170405 10 2 free base) NLX 204 Hydrochloride 2170405-10-2 NLX204 hydrochloride(2170405102 free base) Inhibitor inhibitor inhibit