Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fluvoxamine maleate (DU-23000 (maleate)) is a selective serotonin reuptake inhibitor that is used in the treatment of depression and a variety of anxiety disorders.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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10 mg | 在庫あり | ¥ 11,000 | |||
25 mg | 在庫あり | ¥ 14,500 | |||
50 mg | 在庫あり | ¥ 18,000 | |||
100 mg | 在庫あり | ¥ 27,000 | |||
200 mg | 在庫あり | ¥ 40,000 | |||
500 mg | 在庫あり | ¥ 67,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,000 |
説明 | Fluvoxamine maleate (DU-23000 (maleate)) is a selective serotonin reuptake inhibitor that is used in the treatment of depression and a variety of anxiety disorders. |
In vitro | Fluvoxamine increases [5-HT]ex levels in rat the prefrontal cortex and thalamus, and also increases [DA]ex levels in the striatum. [1] Fluvoxamine maleate ameliorates tactile allodynia via spinal 5-HT2A/2C receptors, by acting on the receptors or 5-HT neurons. [2] |
In vivo | Fluvoxamine maleate also exhibits the antinociception in a dose-dependent manner in the paw pressure test in non-ligated mice. Fluvoxamine maleate also induces antinociceptive effect in the acute paw pressure test, and this effect is antagonized by the 5-HT3 receptor antagonist granisetron. [2] Fluvoxamine (10 and 30 mg/kg, i.p.) enhances synaptic efficacy in the hippocampo-mPFC pathway in a dose-dependent manner in the rat hippocampo-medial prefrontal cortex (mPFC). [3] Fluvoxamine (10 and 30 mg/kg, i.p.) suppresses long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP is completely reversed by the 5-HT(1A) receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by the 5-HT(4) receptor antagonist GR 113808 (20 mg/rat, i.c.v.) and the 5-HT(7) receptor antagonist DR 4004 (10 mg/rat, i.c.v.). [4] Fluvoxamine maleate reinforces the response to norepinephrine of isolated rat vas deferens incubated in Krebs-Henseleit solution. Fluvoxamine maleate and Fluoxetine hydrochloride inhibit the contraction induced by potassium ion on the isolated rat uterus preparation with IC50 of 3.99 μM and 18.2 μM, respectively. [5] |
別名 | MK-264, DU-23000 (maleate) |
分子量 | 434.41 |
分子式 | C19H25F3N2O6 |
CAS No. | 61718-82-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (138.12 mM)
You can also refer to dose conversion for different animals. 詳細
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Fluvoxamine maleate 61718-82-9 GPCR/G Protein Neuroscience 5-HT Receptor Serotonin Transporter inhibit SLC6A4 DU-23000 Fluvoxamine MK 264 DU23000 MK264 Fluvoxamine Maleate SERT 5-HTT MK-264 DU 23000 DU-23000 (maleate) Inhibitor inhibitor