Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NS3623 is an activator of human ether-a-go-go-related gene potassium channels. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. NS3623 activates the IKr and Ito currents and has an antiarrhythmic effect.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 8,000 | |||
5 mg | 在庫あり | ¥ 18,500 | |||
10 mg | 在庫あり | ¥ 29,500 | |||
25 mg | 在庫あり | ¥ 60,500 | |||
50 mg | 在庫あり | ¥ 98,500 | |||
100 mg | 在庫あり | ¥ 147,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 20,500 |
説明 | NS3623 is an activator of human ether-a-go-go-related gene potassium channels. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. NS3623 activates the IKr and Ito currents and has an antiarrhythmic effect. |
In vitro | Administering NS3623 (5 μM) significantly enhances the tail current magnitude in isolated canine cardiomyocytes, corroborating earlier evidence that this compound augments IKr. Specifically, NS3623 boosts IKr tail currents by 60% in normal Mid cells and by 68% in cells cultured for 48 hours, at a +50 mV activating pulse. Furthermore, although the baseline IKr in cells cultured for 48 hours markedly declines compared to freshly isolated cells—from 0.47 ± 0.08 pA/pF to 0.28 ± 0.06 pA/pF—NS3623 application elevates IKr in these cultured Mid cells. An analysis of the current-voltage (I-V) relationship for IKr tail current reveals that NS3623 increases current density in Mid cells cultured for both one and two days. |
In vivo |
NS3623 (30 mg/kg; i.v.; lasting for 3 minutes) shortens the corrected QT interval by 25 +/- 4% in anaesthetized guinea pigs. NS3623 (50 mg/kg) immediately reduces the QTcF interval and remains obviously shortened for approximately 30 minutes. NS3623 (50 mg/kg) shortens the QT interval by 30 +/- 6% in conscious guinea pigs [1]. |
分子量 | 427.18 |
分子式 | C15H10BrF3N6O |
CAS No. | 343630-41-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9.17 mg/ml (21.46 mM)
You can also refer to dose conversion for different animals. 詳細
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NS3623 343630-41-1 Membrane transporter/Ion channel Potassium Channel channels midmyocardial cardiomyocytes current ion canine Potassium KcsA Inhibitor inhibit NS 3623 cells Antiarrhythmic effect NS-3623 inhibitor