| TN2322 |
Yangambin
|
|
Calcium Channel
,
PAFR
|
|
Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibiti... |
| T6S1418 |
Praeruptorin C
|
|
Antioxidant
,
Calcium Channel
|
|
1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors ... |
| T4S1876 |
3-Deoxyaconitine
|
|
Sodium Channel
|
|
3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the rele... |
| T8787 |
Drotaverine hydrochloride
|
|
PDE
|
|
Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor，and is an antispasmodic drug, used to enhance cervical dilation during childbirth. Drotaverine hydrochloride is structurally rela... |
| T8206 |
Cycleanine
|
|
Others
|
|
Cycleanine has potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities. |
| T0728 |
Ethosuximide
|
Zarontin |
Calcium Channel
|
|
Ethosuximide (Zarontin) is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other types of seizures. |
| T3904 |
Gomisin J
|
|
Calcium Channel
,
AMPK
|
|
Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK... |
| T5723 |
Menthol
|
DL-Menthol |
Others
,
Calcium Channel
|
|
Menthol (DL-Menthol) is an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. |
| T10024 |
1-Octanol
|
Octanol |
Calcium Channel
,
Endogenous Metabolite
|
|
1-Octanol, a saturated fatty alcohol, functions as an inhibitor of T-type calcium channels (T-channels), showing an inhibitory concentration (IC50) of 4 μM for native T-currents[1]. Additionally, 1-Octanol is recognized ... |
| T4590 |
(+)-Kavain
|
Kavain,L-KAWAIN,(R)-KAWAIN |
Calcium Channel
,
GABA Receptor
,
Sodium Channel
,
Monoamine Transporter
|
|
(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B. |
| T15027 |
Cyclopiazonic acid
|
|
Calcium Channel
|
|
Cyclopiazonic acid (CPA) is a neurotoxic secondary metabolite (SM) made by A. flavus. Cyclopiazonic acid (CPA) is an endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA)nanomolar inhibitor and a potent inducer of ce... |
| T4S1422 |
Praeruptorin E
|
|
Others
,
Calcium Channel
|
|
1. Praeruptorin C and E can relax swine coronary artery and decrease contractility in guinea-pig left atria, these effects are similar in many respects to those displayed by drugs that have calcium entry blocking activit... |
| T7056 |
Dronedarone
|
SR 33589 |
P450
,
Potassium Channel
,
Calcium Channel
,
Sodium Channel
,
Adrenergic Receptor
,
AChR
,
Autophagy
|
|
Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation. |
| T8299 |
Dimethyl lithospermate B
|
dmLSB |
Sodium Channel
|
|
Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. |
| T3021 |
Bulleyaconitine A
|
Bulleyaconi cine A |
Sodium Channel
|
|
Bulleyaconitine A (Bulleyaconi cine A), an analgesic and antiinflammatory drug isolated from Aconitum plants, has several potential targets, such as voltage-gated Na+ channels. |
| T3013 |
Catharanthine tartrate
|
Catharanthine hemitartrate |
Others
,
Calcium Channel
|
|
Catharanthine tartrate (Catharanthine hemitartrate) is an alkaloid from periwinkle that inhibits voltage-gated L-type calcium channels and has antitumor and hypotensive activities. |
| TQ0302 |
Thapsigargin
|
|
Apoptosis
,
SARS-CoV
,
Calcium Channel
|
|
Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking ... |
| T7177 |
Capsazepine
|
|
Apoptosis
,
TRP/TRPV Channel
|
|
Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of chilli pepper) which activates the TRPV1 ion channel. It is ... |
| T6856 |
Halofuginone
|
Tempostatin,empostatin,RU-19110 |
Calcium Channel
,
DNA/RNA Synthesis
,
Sodium Channel
,
Parasite
,
TGF-beta/Smad
|
|
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal. |
| TN1008 |
Psoralenoside
|
|
CaMK
,
Calcium Channel
,
Histamine Receptor
|
|
Psoralenoside is a natural product isolated from the fruits of Psoralea corylifolia, shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity. |
| T6S1500 |
Ginsenoside Rf
|
Ginsenoside-Rf,Panaxoside Rf |
Calcium Channel
,
Endogenous Metabolite
|
|
Ginsenoside Rf (Panaxoside Rf) is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel. |
| T2782 |
Catharanthine
|
(+)-3, 4-Didehydrocoronaridine,(+)-3,4-Didehydrocoronaridine |
Calcium Channel
,
AChR
|
|
Catharanthine ((+)-3,4-Didehydrocoronaridine) suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM). |
| T12514 |
Podocarpic acid
|
|
Others
,
TRP/TRPV Channel
|
|
Podocarpic acid is a natural product and a novel TRPA1 activator. |
| T3524 |
Halofuginone hydrobromide
|
Tempostatin,RU-19110 (hydrobromide),Stenorol |
Others
,
Calcium Channel
,
DNA/RNA Synthesis
,
Sodium Channel
,
Parasite
,
TGF-beta/Smad
|
|
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce... |
| T4727 |
Taurolithocholic acid sodium salt
|
Sodium taurolithocholate |
Others
,
Calcium Channel
|
|
Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but not to M2 or M3 receptors. |
| TN7108 |
Urolithin C
|
|
Apoptosis
,
Calcium Channel
,
Reactive Oxygen Species
,
IGF-1R
,
Endogenous Metabolite
|
|
Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway. |
| T4550 |
Ajmaline
|
Cardiorythmine,Raugalline,Tachmalin,(+)-Ajmaline |
Sodium Channel
|
|
Ajmaline (Cardiorythmine) is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. Ajmaline inhibits cardiac Kv1.5 and... |
| T4S1419 |
(±)-Praeruptorin A
|
Praeruptorin A,(-)-Praeruptorin A |
p38 MAPK
,
Calcium Channel
,
Akt
|
|
1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion ... |
| T6S1684 |
8-Gingerol
|
|
Antioxidant
,
Antibacterial
,
TRP/TRPV Channel
|
|
1. 8-Gingerol has antioxidant activity. 2. 8-Gingerol has antimycobacterial activity. 3. 8-Gingerol could be used as an effective skin-whitening agent. 4. 8-Gingerol shows antipyretic and anti-inflammation characteristic... |
| T3S1916 |
Heteroclitin D
|
|
Calcium Channel
|
|
1. Heteroclitin D can inhibit L-type calcium channels. 2. Heteroclitin D might be a valuable antitumor promoter or chemopreventor. |
| T5701 |
OPHIOPOGONIN D
|
|
RAAS
,
Calcium Channel
,
NF-κB
,
PPAR
|
|
Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation. |
| T2807 |
Caffeic Acid
|
|
Lipoxygenase
,
Endogenous Metabolite
,
TRP/TRPV Channel
|
|
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activities. |
| T1221 |
Acetylcholine chloride
|
ACh chloride,Pilofrin |
Calcium Channel
,
Endogenous Metabolite
,
AChR
|
|
Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride (Pilofrin) mimics the parasympathomimetic effect of the endogen... |
| T8288 |
14-Deoxyandrographolide
|
|
Apoptosis
,
Others
|
|
14-Deoxyandrographolide is a bioactive compound of Andrographis paniculata with hepatoprotective efficacy. It desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release. |
| T0167 |
Vinpocetine
|
RGH-4405,Ethyl apovincaminate |
IκB/IKK
,
NF-κB
,
Sodium Channel
,
PDE
|
|
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE). |
| T5S2059 |
Glaucine
|
|
Calcium Channel
,
Dopamine Receptor
,
Influenza Virus
,
Adrenergic Receptor
,
PDE
|
|
Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of h... |
| T11665 |
Ionomycin calcium
|
SQ23377 calcium |
Apoptosis
,
Calcium Channel
,
Antibacterial
,
Antibiotic
,
PKC
|
|
|
| TN6713 |
6-Benzoylheteratisine
|
Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth |
Sodium Channel
|
|
6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) is a Aconitum alkaloid. It can inhibits voltage-gated Na+ channels in rat brain synaptosomes |
| TN4417 |
Larixyl acetate
|
|
Others
|
|
Larixyl acetate is a bioactive chemical. |
| TN1035 |
Irisolidone
|
|
IL Receptor
,
NF-κB
,
Chloride channel
|
|
Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM. |
| T3915 |
Ginsenoside Ro
|
Chikusetsusaponin 5,Polysciasaponin P3,Chikusetsusaponin V |
Calcium Channel
,
Reductase
,
Prostaglandin Receptor
|
|
Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with an IC50 of 155 μM. |
| T2996 |
Tetrandrine
|
NSC-77037,d-Tetrandrine,Hanfangchin A,Fanchinine,Sinomenine A |
Potassium Channel
,
Calcium Channel
|
|
Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the c... |
| TQ0001 |
1,4-Cineole
|
Isocineole |
Endogenous Metabolite
,
TRP/TRPV Channel
|
|
1,4-Cineole (Isocineole) is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1. |
| T2878 |
Ginsenoside Rd
|
Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII |
P450
,
Calcium Channel
,
NF-κB
,
COX
,
Endogenous Metabolite
|
|
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors. |
| T3727 |
Methyl syringate
|
Syringic Acid Methyl Ester |
TRP/TRPV Channel
|
|
Methyl syringate (Syringic Acid Methyl Ester) has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K. pictus is a specific and selec... |
| TCS0102 |
Pulegone
|
(+)-Pulegone |
Calcium Channel
,
Endogenous Metabolite
,
TRP/TRPV Channel
|
|
1. Pulegone ((+)-Pulegone) has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a verapamil-sensitive psychostimulant effect t... |
| T37709 |
2,2,2-Trichloroethanol
|
|
Potassium Channel
,
Endogenous Metabolite
|
|
2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1].
2,2,2-trichloroethanol activates a nonclassical ... |
| T2952 |
Camphor
|
(±)-Camphor,Bornan-2-one,2-Camphanone,2-Bornanone,Formosa |
Influenza Virus
,
TRP/TRPV Channel
|
|
Camphor (2-Camphanone) is a bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent. |
| T3377 |
L-Phenylalanine
|
(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine |
Calcium Channel
,
Endogenous Metabolite
,
iGluR
|
|
L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels. |
| TN1465 |
Cannabigerol
|
|
NOS
,
5-HT Receptor
,
ROS
|
|
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressur... |
