keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 9,000 | |||
10 mg | 在庫あり | ¥ 15,000 | |||
25 mg | 在庫あり | ¥ 30,000 | |||
50 mg | 在庫あり | ¥ 43,500 | |||
100 mg | 在庫あり | ¥ 65,000 | |||
500 mg | 在庫あり | ¥ 158,000 |
説明 | Nomilin is naturally occurring triterpenoids, have immunomodulatory activity. |
In vitro | Administration of Nomilin significantly retarded endothelial cell proliferation, invasion, migration and tube formation. It also possesses anti-proliferative activity against the number of human cancer cell lines including leukemia (HL-60), ovary (SKOV-3), liver (Hep G2), cervix (HeLa), stomach (NCI-SNU-1), and breast (MCF-7)[2]. Nomilin significantly decreased TRAP-positive multinucleated cell numbers compared with the control and exhibited no cytotoxicity. It decreases bone resorption activity and downregulates osteoclast-specific genes, NFATc1 and TRAP mRNA levels. Furthermore, Nomilin suppressed MAPK signaling pathways. Thus, Nomilin has inhibitory effects on osteoclastic differentiation in vitro[3]. |
In vivo | Nomilin is an effective inducer of gluthathione S-transferase activity in mice and to inhibit carcinogenesis in the hamster buccal pouch assay. Nomilin can shorten anaesthetic-induced sleeping time in mice, probably through a stimulant action on the central nervous system [1]. Nomilin significantly inhibited tumour-directed capillary formation. Serum proinflammatory cytokines such as IL-1β, IL-6, TNF-α and GM-CSF and also serum NO levels were significantly reduced by the treatment of nomilin. Administration of Nomilin significantly reduced the serum level of VEGF, a proangiogenic factor and increased the antiangiogenic factors TIMP-1 and IL-2 [2]. |
細胞研究 | Cell lines: HUVECs. Concentrations: 5 μg-500 μg/ml. Incubation Time: 48 h. Method:. HUVECs were seeded (5000 cells/well) in 96-well flat-bottomed titer plate and incubated for 24 h at 37 °C in 5% CO2 atmosphere. Different concentrations of Nomilin (5 μg-500 μg/ml) were added and incubated further for 48 h. Before 4 h completion of incubation, 20 μl MTT (5 mg/ml) was added. Percentage of dead cells was determined using an ELISA plate reader set to record absorbance at 570 nm. |
動物実験 | Animal Models: Four to six week old male C57BL/6 mice. Formulation: light paraffin oil. Dosages: 6 mg/kg, I.P. |
植物由来 |
分子量 | 514.56 |
分子式 | C28H34O9 |
CAS No. | 1063-77-0 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
Ethanol: Insoluble
DMSO: 50 mg/mL (97.17 mM)
You can also refer to dose conversion for different animals. 詳細
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Nomilin 1063-77-0 MAPK inhibit anti-hyperglycemic limonoid ischemia-reperfusion anti-obesity Inhibitor compound inhibitor