Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ONO-4059 analog (ONO-WG-307)ue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.
説明 | ONO-4059 analog (ONO-WG-307)ue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1. |
ターゲット&IC50 | BTK:23.9 nM |
In vitro | In TMD-8 cells, ONO-4059 inhibits cell growth with IC50 of 3.59 nM, and induces cell apoptosis. The combination of of ONO-4059 with doxorubicin, etoposide, vincristine or dexamethasone causes the increased apoptosis ratio. [1] |
別名 | ONO-4059 analogue, ONO-WG-307, GS-4059 analog |
分子量 | 456.5 |
分子式 | C25H24N6O3 |
CAS No. | 1351635-67-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 16 mg/mL (35 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ONO-4059 analog 1351635-67-0 Angiogenesis Apoptosis Tyrosine Kinase/Adaptors BTK Inhibitor Btk inhibit ONO4059 ONO 4059 ONO-4059 analogue ONO-WG307 ONO-WG-307 ONO 4059 analog Bruton tyrosine kinase ONO-WG 307 ONO-4059 GS-4059 analog ONO4059 analog inhibitor