Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50=0.87 μM). It is development as an injectable agent for the treatment of postoperative pain.
説明 | Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50=0.87 μM). It is development as an injectable agent for the treatment of postoperative pain. |
ターゲット&IC50 | 5-HT2A receptor:1.3 μM, GlyT2:0.86 μM, P2X3 (rat):0.87 μM |
分子量 | 430.97 |
分子式 | C21H35ClN2O5 |
CAS No. | 1440796-75-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (116.02 mM)
You can also refer to dose conversion for different animals. 詳細
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Opiranserin hydrochloride 1440796-75-7 GPCR/G Protein Membrane transporter/Ion channel Neuroscience 5-HT Receptor P2X Receptor GlyT VVZ 149 analgesic postoperative VVZ-149 5-hydroxytryptamine Receptor anti-inflammatory Serotonin Receptor Inhibitor pain Opiranserin non-opioid inhibit P2XRs Opiranserin Hydrochloride VVZ149 Glycine transporters inhibitor