keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 71,000 |
5 mg | 在庫あり | ¥ 173,000 |
10 mg | 在庫あり | ¥ 243,500 |
25 mg | 在庫あり | ¥ 360,500 |
50 mg | 在庫あり | ¥ 486,500 |
100 mg | 在庫あり | ¥ 656,500 |
説明 | Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively. |
ターゲット&IC50 | OX2:36 nM, OX1:420 nM |
In vitro | Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor[1]. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50 of 36 nM in the binding assay and an EC50 of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50 in the competitive binding assay and the EC50 in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively[2]. |
In vivo | Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively[2]. |
別名 | Rat orexin B, Orexin B (mouse) Acetate, Orexin B, rat, mouse Acetate(202801-92-1 free base) |
分子量 | 2996.45 |
分子式 | C128H219N45O36S |
CAS No. | TP1045L |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Insoluble
H2O: 2.5 mM
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Orexin B, rat, mouse Acetate TP1045L GPCR/G Protein Neuroscience OX Receptor Orexin B Acetate Rat orexin B Orexin B (mouse) Acetate Orexin B, rat, mouse Acetate(202801-92-1 free base) Orexin B Inhibitor inhibitor inhibit