Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PD-1/PD-L1-IN-10 is an orally active PD-1/PD-L1 inhibitor (IC50 of 2.7 nM) with potent anticancer efficacy.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 10,000 | |||
5 mg | 在庫あり | ¥ 22,500 | |||
10 mg | 在庫あり | ¥ 39,500 | |||
25 mg | 在庫あり | ¥ 76,500 | |||
50 mg | 在庫あり | ¥ 137,000 | |||
100 mg | 在庫あり | ¥ 195,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 27,000 |
説明 | PD-1/PD-L1-IN-10 is an orally active PD-1/PD-L1 inhibitor (IC50 of 2.7 nM) with potent anticancer efficacy. |
ターゲット&IC50 | PD-1/PD-L1:2.7 nM |
In vitro | PD-1/PD-L1-IN-10 (compound B2) effectively enhances interferon-gamma secretion in vitro in a dose-dependent manner, even at a minimal concentration of 1 nM[1]. It does not compromise the viability of Lewis lung carcinoma (LLC) cells or lymph node T-cells[1]. Furthermore, this compound significantly stabilizes PD-L1 protein levels within LLC cells across a range of 0-100 nM, demonstrating a dose-dependent effect on PD-L1 protein stability at 58 °C. This suggests that PD-1/PD-L1-IN-10 (compound B2) can penetrate LLC cells and directly interact with PD-L1 protein[1]. |
In vivo | PD-1/PD-L1-IN-10 (compound B2, 5 mg/kg, intragastric gavage) exhibits potent in vivo anticancer efficacy in an LLC-bearing allograft mouse model. PD-1/PD-L1-IN-10 (compound B2) effectively blocks tumor cell proliferation and induces apoptosis in LLC tumor tissues.[1]. |
分子量 | 581.62 |
分子式 | C33H31N3O7 |
CAS No. | 2487550-41-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (171.93 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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PD-1/PD-L1-IN-10 2487550-41-2 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 Lewis T-lymphocyte tumor IFN-γ Inhibitor lung LLC inhibit PD1/PDL1IN10 PD 1/PD L1 IN 10 carcinoma PD-1/PD-L-1-IN-10 inhibitor