Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-4191834 is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC50=229 nM). PF-4191834 shows ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX and displays no activity toward the cyclooxygenase enzymes. PF-4191834 is also effective in inflammation and pain.
説明 | PF-4191834 is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC50=229 nM). PF-4191834 shows ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX and displays no activity toward the cyclooxygenase enzymes. PF-4191834 is also effective in inflammation and pain. |
In vitro | PF-4191834 exerts a concentration-dependent inhibition of human 5-LOX (IC50: 130 nM and an IC80: 370 nM). PF-4191834 inhibits the synthesis of the 5-LOX products 5-HETE, 5-oxo-ETE, LTB4, and LTE4 with estimated IC50 values between 100 and 190 nM. However, it does not inhibit significantly the COX-1/2 enzymes or the 12- or 15-LOX enzymes at concentrations up to 30 μM[1]. |
別名 | PF-04191834 |
分子量 | 393.5 |
分子式 | C22H23N3O2S |
CAS No. | 1029317-21-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (127.06 mM)
You can also refer to dose conversion for different animals. 詳細
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PF-4191834 1029317-21-2 Metabolism Lipoxygenase inhibit LOX PF 4191834 PF-04191834 PF4191834 Inhibitor PF04191834 PF 04191834 inhibitor