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635

阻害剤

110

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T39986	LOX-IN-3 dihydrochloride		Lipoxygenase
	LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX). LOX-IN-3 dihydrochloride inhibited bovine LOX (IC50<10 μM) and human LOXL2 (IC50<1 μM)activities.		Lipoxygenase
T77528	5-LOX-IN-2		Apoptosis , Lipoxygenase
	5-LOx-in-2 is a 5-lipoxygenase inhibitor (5-LOX) with an IC50 value of 0.33 μM. 5-lox-in-2 inhibits 5-LOX action IN a dose-dependent manner. 5-LOX-IN-2 can reduce the cell activity of kidney cancer cells and induce apopt...		Apoptosis , Lipoxygenase
T65427	5-LOX inhibitor	1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one	Lipoxygenase
	5-LOX inhibitor (1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one) is one of the impurities of itraconazole, a selective LOX-5 inhibitor.		Lipoxygenase
T77677	12R-LOX-IN-2		Lipoxygenase
	12R-LOX-IN-2 is an inhibitor of 12R-lipoxygenase (12R-LOX).12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and inhibits colony formation.12R-LOX-IN-2 also decreases the protein...		Lipoxygenase
T61211	5-LOX-IN-1		Lipoxygenase
	5-LOX-IN-1 is a 5-Lipoxygenase (5-LOX) inhibitor (IC50: 2.3 μM).5-LOX-IN-1 can be used for cancer research.		Lipoxygenase
T38006	LOX-IN-3
	LOX-IN-3, an orally active inhibitor of lysyl oxidase (LOX), holds potential application in the fields of fibrosis, cancer, and angiogenesis research[1].
T36169	15-LOX-1 inhibitor 1
	9c(i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1; IC50 = 0.19 μM).1 It decreases LPS- and IFN-γ-induced NF- B activity in RAW-Blue cells when used at concentrations of 0.2, 1, and 5 μM. 9c(i472) reduces LPS- and I...
T83457	12R-LOX-IN-1
	12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX. It suppresses the hyperproliferative condition and the ability to form colonies in Imiquimod-induced psoriatic keratinocytes, as well as r...
T78820	5-LOX-IN-5		Lipoxygenase
	Compound 29, also known as 5-LOX-IN-5, is a 5-lipoxygenase (5-LOX) inhibitor with an inhibitory concentration 50 (IC50) of 56 nM, utilized in research pertaining to neurodegenerative diseases [1].		Lipoxygenase
T60630	COX/5-LOX-IN-1
	COX/5-LOX-IN-1 (compound 6b) is a potent COX/5-LOX dual inhibitor with the potential for inflammation diseases research. COX/5-LOX-IN-1 has IC50s of 1.07, 0.55, and 0.28 μM for COX-1, COX-2, and 5-LOX enzyme, respectivel...
T62350	XO/COX/LOX-IN-1
	XO/COX/LOX-IN-1 is a potent inhibitor of xanthine oxidase/cyclooxygenase/lipoxygenase XO/COX/LOX. XO/COX/LOX-IN-1 can be used in the study of inflammatory, cancer and metabolic diseases.
T79158	H15-LOX-2 inhibitor 1		Lipoxygenase
	Compound 105 (h15-LOX-2 inhibitor 1) is a potent inhibitor of human epithelial 15-lipoxygenase-2 (h15-LOX-2), exhibiting an IC50 of 0.34 μM [1].		Lipoxygenase
T61479	LOX-IN-3 dihydrochloride monohydrate
	LOX-IN-3 dihydrochloride monohydrate (Compound 33) is a lysyl oxidase (LOX) inhibitor with oral activity. It is specifically designed for research purposes in the areas of fibrosis, cancer, and angiogenesis [1].
T61674	COX-2/5-LOX-IN-1
	COX-2/5-LOX-IN-1 (compound 3a), a benzothiophen-2-yl pyrazole carboxylic acid derivative, is a potent and dual inhibitor of COX-2 / 5-LOX. It exhibits superior analgesic and anti-inflammatory properties compared to Celec...
T79362	COX-2/15-LOX-IN-4		Lipoxygenase
	COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor with IC50 values of 0.075 μM for COX-2 and 1.97 μM for 15-LOX. It inhibits LPS-induced production of pro-inflammatory cytokines (IL-6, ROS) and exhibits targeted anti-i...		Lipoxygenase
T61910	COX-2/5-LOX-IN-2
	COX-2/5-LOX-IN-2 is a benzothiophen-2-ylpyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 (5b) inhibited both COX-2 and 5-LOX. The IC50s of COX-2/5-LOX-IN-2 inhibiting COX-1, COX-2 and 5-LOX were 5.40, 0.01 and 1.78 ...
T79361	COX-2/15-LOX-IN-3		Lipoxygenase
	COX-2/15-LOX-IN-3 (compound 5k) serves as a dual inhibitor for COX-2 and 15-LOX, demonstrating inhibitory concentrations (IC50) of 0.075 μM and 1.97 μM, respectively. This compound effectively suppresses LPS-induced cell...		Lipoxygenase
T61352	COX-2/5-LOX-IN-3
	COX-2/5-LOX-IN-3 (compound 5b) is a powerful and dual inhibitor of COX-2 and 5-LOX, with IC50 values of 45.73 μM, 5.45 μM, and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. This compound, COX-2/5-LOX-IN-3, shows pro...
T62998	COX-2/15-LOX-IN-1
	COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and 15-lipoxygenase (15-LOX) inhibitor that acts on COX-1 (IC50: 10.65 μM), COX-2 (IC50: 0.075 μM) and 15-LOX (IC50: 2.98 μM). 25 has an anti-inflammatory effect.
T79360	COX-2/15-LOX-IN-2		Lipoxygenase
	COX-2/15-LOX-IN-2 is a potent inhibitor of both COX-2 and 15-LOX, demonstrating IC50 values of 0.065 μM for COX-2 and 1.86 μM for 15-LOX. Additionally, it exhibits significant antioxidant activity [1].		Lipoxygenase
T8356	FPL 62064		Lipoxygenase , COX
	FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively).		Lipoxygenase , COX
T4347	ML355		Lipoxygenase
	ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.		Lipoxygenase
T8950	CAY10698		Lipoxygenase
	CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 µM).		Lipoxygenase
T9108	BI-0115		Lipoxygenase
	BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX...		Lipoxygenase
T6243	U-73122	U73122	Phospholipase , Ferroptosis , Lipoxygenase
	U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.		Phospholipase , Ferroptosis , Lipoxygenase
T8794	4-MMPB	15-Lipoxygenase Inhibitor 1	Apoptosis , Others , Lipoxygenase
	15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB (15-Lipoxygenase Inhibitor 1) has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxyg...		Apoptosis , Others , Lipoxygenase
T6568	Licofelone	ML-3000	Apoptosis , Lipoxygenase , COX
	Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis. Licofelone is both an analgesic and an anti-inflammatory. Inhibition of 5-LOX may reduce the gastrointestinal toxicity ass...		Apoptosis , Lipoxygenase , COX
T21902	ML351		Lipoxygenase
	ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).		Lipoxygenase
T16503	PF-4191834	PF-04191834	Lipoxygenase
	PF-4191834 is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC50=229 nM). PF-4191834 shows ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX and displays no activity tow...		Lipoxygenase
T7540	2,5-Di-tert-butylhydroquinone	BHQ	Calcium Channel , Lipoxygenase , COX
	2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.		Calcium Channel , Lipoxygenase , COX
T21746	Terameprocol	tetramethyl Nordihydroguaiaretic Acid,EM-1421	HIV Protease
	Terameprocol (EM-1421) is a synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol sh...		HIV Protease
T10098	PGS-IN-1	KME-4	Lipoxygenase , Prostaglandin Receptor
	PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).		Lipoxygenase , Prostaglandin Receptor
T22398	Phenidone	1-phenyl-3-pyrazolidinone	Lipoxygenase , COX
	Phenidone (1-phenyl-3-pyrazolidinone) is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes[1]. The lipoxyg...		Lipoxygenase , COX
T0477	Zileuton	Abbott 64077,A 64077	Ferroptosis , Lipoxygenase , COX
	Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; ca...		Ferroptosis , Lipoxygenase , COX
T6576	Malotilate	Malotilatum,NKK 105,Kantec	Lipoxygenase
	Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis.		Lipoxygenase
T5200	Indirubin-3'-monoxime	Indirubin-3'-oxime	GSK-3 , Lipoxygenase , CDK
	Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).		GSK-3 , Lipoxygenase , CDK
T7724	Tepoxalin	RWJ-20485,RWJ20485,ORF20485,ORF-20485,RWJ 20485,ORF 20485	Lipoxygenase , COX
	Tepoxalin (RWJ 20485) is a 5-lipoxygenase inhibitor potentially for the treatment of asthma, osteoarthritis. Tepoxalin inhibits COX-1, COX-2, and 5-LOX. Tepoxalin is a potent inhibitor of sheep seminal vesicle cyclooxyge...		Lipoxygenase , COX
T6893	MK-886	MK886,L 663536	Apoptosis , Leukotriene Receptor , COX , PPAR , FLAP
	MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.		Apoptosis , Leukotriene Receptor , COX , PPAR , FLAP
T27026	CJ-13,610	CJ 13610,CJ-13610	Lipoxygenase
	CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expression of IL-6 mRNA in macrophages.		Lipoxygenase
T67908	ThioLox		Lipoxygenase
	ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with IC50 value of 12 μM. ThioLox shows anti-inflammatory and neuroprotective properties. It has anti-inflammatory and neuroprotective effects, and has a st...		Lipoxygenase
T8142	Difloxacin hydrochloride	Difloxacin HCl	Antibacterial , Antibiotic
	Difloxacin hydrochloride (Difloxacin HCl) is a fluoroquinolone antibiotic, is a broad-spectrum antibacterial drug.		Antibacterial , Antibiotic
T15777	Loxoribine	RWJ 21757,7-Allyl-8-oxoguanosine	Influenza Virus , TLR
	Loxoribine (RWJ 21757) is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant ...		Influenza Virus , TLR
T31482	Diloxanide	Diloxanid,RD 3803,RD3803,RD-3803,Diloxanida	Parasite
	Diloxanide (RD3803) is an endomoeba insecticide. It is considered to be the luminal agent of choice for patients with mild enteroamoebiasis or asymptomatic cysts.		Parasite
T0250	Ciprofloxacin monohydrochloride	Bay-09867 (hydrochloride),Ciprofloxacin HCl,Ciprofloxacin hydrochloride	DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
	Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.		DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
T19239	Cicloxilic acid	Cycloxilic acid	Others
	Cicloxilic acid（Cycloxilic acid） has choleretic activity and inhibits biliary cholesterol output.		Others
T8747	Levofloxacin hydrochloride		DNA gyrase , Topoisomerase
	Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inh...		DNA gyrase , Topoisomerase
T1733	Ciprofloxacin EP IMpurity A	Q-Acid,Fluoroquinolonic Acid,Ciprofloxacin Impurity A	Antibiotic
	Ciprofloxacin EP IMpurity A (Fluoroquinolonic Acid) is an antibiotic and antimicrobial agent.		Antibiotic
T38003	Levofloxacin N-oxide		Others
	Levofloxacin N-oxide is an inactive metabolite of the antibiotic levofloxacin . Levofloxacin N-oxide is also a degradation product of levofloxacin that is formed through exposure to daylight or hydrogen peroxide.		Others
T7592	Trifloxystrobin	CGA 279202	Antifungal
	Trifloxystrobin (CGA 279202) is a fungicide that inhibits the growth of R. solani isolates from sugar beet crops.EC50s of 23.0 μg/L and 1.7 μg/L for Daphnia magna neonate and embryos, respectively.		Antifungal
T3117	Marbofloxacin	Marbofloxacine,Zeniquin,Marbocyl	Topoisomerase , Antibacterial , Antibiotic
	Marbofloxacin (Zeniquin) is an effective, broad-spectrum antibiotic of bacterial, which inhibits DNA replication.		Topoisomerase , Antibacterial , Antibiotic

Compounds

LOX-IN-3 dihydrochloride

Target: Apoptosis, Lipoxygenase

5-LOX inhibitor

T65427

Synonym: 1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

15-LOX-1 inhibitor 1

h15-LOX-2 inhibitor 1

T79158

Synonym:

Target: Lipoxygenase

LOX-IN-3 dihydrochloride monohydrate

Target: Lipoxygenase, COX

Target: Phospholipase, Ferroptosis, Lipoxygenase

4-MMPB

T8794

Synonym: 15-Lipoxygenase Inhibitor 1

Target: Apoptosis, Others, Lipoxygenase

Licofelone

T6568

Synonym: ML-3000

Target: Apoptosis, Lipoxygenase, COX

2,5-Di-tert-butylhydroquinone

T7540

Synonym: BHQ

Target: Calcium Channel, Lipoxygenase, COX

Terameprocol

T21746

Synonym: tetramethyl Nordihydroguaiaretic Acid,EM-1421

Target: Lipoxygenase, Prostaglandin Receptor

Phenidone

T22398

Synonym: 1-phenyl-3-pyrazolidinone

Target: Lipoxygenase, COX

Zileuton

T0477

Synonym: Abbott 64077,A 64077

Target: Ferroptosis, Lipoxygenase, COX

Malotilate

T6576

Synonym: Malotilatum,NKK 105,Kantec

Target: Lipoxygenase

Indirubin-3'-monoxime

T5200

Synonym: Indirubin-3'-oxime

Target: GSK-3, Lipoxygenase, CDK

Tepoxalin

T7724

Synonym: RWJ-20485,RWJ20485,ORF20485,ORF-20485,RWJ 20485,ORF 20485

Target: Lipoxygenase, COX

MK-886

T6893

Synonym: MK886,L 663536

Target: Apoptosis, Leukotriene Receptor, COX, PPAR, FLAP

CJ-13,610

T27026

Synonym: CJ 13610,CJ-13610

Difloxacin hydrochloride

T8142

Synonym: Difloxacin HCl

Target: Antibacterial, Antibiotic

Loxoribine

T15777

Synonym: RWJ 21757,7-Allyl-8-oxoguanosine

Target: Influenza Virus, TLR

Diloxanide

T31482

Synonym: Diloxanid,RD 3803,RD3803,RD-3803,Diloxanida

Target: Parasite

Ciprofloxacin monohydrochloride

T0250

Synonym: Bay-09867 (hydrochloride),Ciprofloxacin HCl,Ciprofloxacin hydrochloride

Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic

Cicloxilic acid

T19239

Synonym: Cycloxilic acid

Target: Others

Levofloxacin hydrochloride

T8747

Synonym:

Target: DNA gyrase, Topoisomerase

Ciprofloxacin EP IMpurity A

T1733

Synonym: Q-Acid,Fluoroquinolonic Acid,Ciprofloxacin Impurity A

Synonym: Marbofloxacine,Zeniquin,Marbocyl

Target: Topoisomerase, Antibacterial, Antibiotic

カタログ番号	製品名	別名	ターゲット
T6S0413	Pectolinarigenin	Pectolinaringenin	Others , Lipoxygenase , COX
	1. Pectolinarigenin (Pectolinaringenin) exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity and that they may inhibit eicosanoid formation in ...		Others , Lipoxygenase , COX
T3399	Psoralidin		Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial
	Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties.
T8260	4',5-Dihydroxyflavone		Lipoxygenase , Glucosidase
	4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).		Lipoxygenase , Glucosidase
T2807	Caffeic Acid		Lipoxygenase , Endogenous Metabolite , TRP/TRPV Channel
	Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activities.		Lipoxygenase , Endogenous Metabolite , TRP/TRPV Channel
TQ0180	Chebulagic acid		SARS-CoV , Influenza Virus , Lipoxygenase , COX
	Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.		SARS-CoV , Influenza Virus , Lipoxygenase , COX
T8002	3-Hydroxycoumarin		Lipoxygenase
	3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitors		Lipoxygenase
TN2330	Phenethyl ferulate	Caffeic Acid 3-Methyl Phenethyl Ester	Lipoxygenase , COX
	Phenethyl ferulate (Caffeic Acid 3-Methyl Phenethyl Ester) has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane induced colon tumors. It shows inhibitory a...		Lipoxygenase , COX
T5714	5-O-Demethylnobiletin	5-DEMETHYLNOBILETIN	Leukotriene Receptor , Lipoxygenase
	5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2.		Leukotriene Receptor , Lipoxygenase
TJS2190	Nordihydroguaiaretic acid	NDGA,Dihydronorguaiaretic Acid	Antioxidant , Ferroptosis , Lipoxygenase , Autophagy
	Nordihydroguaiaretic acid (NDGA) (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibito...		Antioxidant , Ferroptosis , Lipoxygenase , Autophagy
TN5634	Aureusidin	Auresudidin,Auresidin	Antioxidant , Reactive Oxygen Species , Lipoxygenase
	Aureusidin (Auresidin) shows antioxidant and lipoxygenase inhibitory activity with anti-inflammatory effects.		Antioxidant , Reactive Oxygen Species , Lipoxygenase
T5759	S-(+)-Marmesin	(+)-Marmesin,(S)-Marmesin,marmesin	Lipoxygenase , COX
	S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.		Lipoxygenase , COX
T3S0153	Xanthatin		Apoptosis , VEGFR , Lipoxygenase , Wnt/beta-catenin , Antibacterial
	1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSCLC. 4. Xanthatin can inhibit murine melanoma B16-F1 cell pr...
TN1097	β-Boswellic acid	Beta-boswellic acid	Lipoxygenase , DNA/RNA Synthesis
	β-Boswellic acid (Beta-boswellic acid) and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities.		Lipoxygenase , DNA/RNA Synthesis
T3384	Wedelolactone	IKK Inhibitor II	Apoptosis , NF-κB , Lipoxygenase , Caspase
	Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.		Apoptosis , NF-κB , Lipoxygenase , Caspase
TN1255	3-O-Acetyl-11-hydroxy-beta-boswellic acid		Lipoxygenase
	3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).		Lipoxygenase
TN1182	11-Keto-beta-boswellic acid	11-Keto-beta-boswellic acid	Leukotriene Receptor , NF-κB , Lipoxygenase
	11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenas...		Leukotriene Receptor , NF-κB , Lipoxygenase
TN1343	8-Geranyloxypsoralen		Anti-infection , P450 , BACE
	8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arterial tissues. 8-Geranyloxypsoralen possesses nematicidal act...		Anti-infection , P450 , BACE
TN1025	3,29-O-Dibenzoyloxykarounidiol		Others
	3,29-O-Dibenzoyloxykarounidiol is a natural product with regulate blood sugar level, has potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induced by tumor promoter 12-O-tetradecanoylphorbol-13-aceta...		Others
T1306	Norfloxacin	MK-0366	DNA gyrase , Topoisomerase , Endogenous Metabolite , Antibacterial , Antibiotic
	Norfloxacin (MK-0366)(Norxacin) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
T4S1658	Benzoyloxypaeoniflorin	Benzoyloxypeoniflorin	NF-κB , Tyrosinase
	Benzoyloxypaeoniflorin (Benzoyloxypeoniflorin) is a natural product,contributes to improving blood circulation through their inhibitory effects on both platelet aggregation and blood coagulation.		NF-κB , Tyrosinase
T1549	Raloxifene hydrochloride	LY156758 hydrochloride,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl	Estrogen Receptor/ERR , Others , MAO , Estrogen/progestogen Receptor , Autophagy
	Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and chol...
T8130	Ciprofloxacin hydrochloride monohydrate	Oftacilox,Ciprofloxacin hydrochloride hydrate,Bay-09867 hydrochloride monohydrate,Ceprimax,Ciloxan	Antibacterial , Antibiotic
	Ciprofloxacin hydrochloride monohydrate (Bay-09867 hydrochloride monohydrate) is a fluoroquinolone antibiotic,is an antibiotic used to treat a number of bacterial infections		Antibacterial , Antibiotic
T1276	Danofloxacin mesylate	CP 76136-27	DNA/RNA Synthesis , Antibacterial , Antibiotic
	Danofloxacin mesylate (CP 76136-27) is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase.		DNA/RNA Synthesis , Antibacterial , Antibiotic
T5744	7-Prenyloxycoumarin	Nsc267697,7-O-Prenylumbelliferone	Antifungal
	7-Prenyloxycoumarin (Nsc267697) is a natural product from Heracleum dissectum,and possess preventive and therapeutic effects on breast cancer but they have also cytotoxic effects on some other cancer cell lines.		Antifungal
T1121	Podofilox	Podophyllotoxin,(+)-Shikonin	Microtubule Associated , Topoisomerase
	Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irrit...		Microtubule Associated , Topoisomerase
T6567	Levofloxacin	Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin	Topoisomerase , Antibacterial , Antibiotic
	Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.		Topoisomerase , Antibacterial , Antibiotic
T8046	Tosufloxacin tosylate hydrate	Tosufloxacin p-Toluenesulfonate Hydrate,A-61827 tosylate hydrate,T-3262 Tosylate Hydrate	Others , Antibacterial , Antibiotic
	Tosufloxacin tosylate hydrate (A-61827 tosylate hydrate) is a fluoroquinolone antibacterial agent that is used to treat susceptible infections.		Others , Antibacterial , Antibiotic
T8384	Gatifloxacin hydrochloride	AM-1155 (hydrochloride),BMS-206584 (hydrochloride),PD135432 (hydrochloride)	Topoisomerase , Antibacterial , Antibiotic
	Gatifloxacin hydrochloride (AM-1155 hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, which can inhibit the bacterial enzyme DNA rotase and topoisomerase IV.		Topoisomerase , Antibacterial , Antibiotic
T38658	3-(β-D-Glucopyranosyloxy)-1,6-dihydroxy-2-methyl-9,10-anthracenedione
	3-(β-D-Glucopyranosyloxy)-1,6-dihydroxy-2-methyl-9,10-anthracenedione, also known as an anthraquinone, has been specifically extracted from Rubia cordifolia.
TN3295	8alpha-(2-Methylacryloyloxy)hirsutinolide		Others
	8alpha-(2-Methylacryloyloxy)hirsutinolide is a natural product for research related to life sciences. The catalog number is TN3295 and the CAS number is 188293-70-1.		Others
T10197	8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol	8-9-epoxy-3-isobutyryloxy-10-2-methylbutanoyl-thymol	Others
	8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol is a chemical composition of essential oils from Telekia speciosa. It also shows marked antipro-liferative activity against human cancer cell lines in vitro.		Others
TN5915	Caloxanthone B
	Caloxanthone B is a natural product for research related to life sciences. The catalog number is TN5915 and the CAS number is 155233-17-3.
T21098	Decamethylcyclopentasiloxane	Dekamethylcyklopentasiloxan,Cyclopentasiloxane, decamethyl-
	Decamethylcyclopentasiloxane is a cyclic methylsiloxane with volatile properties.
TN1924	Methyl 1,4-bisglucosyloxy-3-prenyl-2-naphthoate		Others
	Methyl 1,4-bisglucosyloxy-3-prenyl-2-naphthoate is a natural product		Others
TN3225	7-Geranyloxy-5-methoxycoumarin		Others
	7-Geranyloxy-5-methoxycoumarin is a naturally occurring compound found in many plants, including the bark of the red maple tree. It has been shown to have anti-inflammatory, antioxidant and anti-tumor properties.		Others
TN5399	4α,8β-Dihydroxy-3α-(2-hydroxy-3-acetoxy-2-methylbutyryloxy)eudesm-7(11)-en-12,8α-olide
	4α,8β-Dihydroxy-3α-(2-hydroxy-3-acetoxy-2-methylbutyryloxy)eudesm-7(11)-en-12,8α-olide is a natural product for research related to life sciences. The catalog number is TN5399 and the CAS number is 1442989-33-4.
T83420	1α, 2α-Diacetoxy-8β-isobutanoyloxy-9α-benzoyloxy-15-β-(β-furancarbonyloxy)-4β, 6β-dihydroxy-β-dihydroagarofuran
	Compound 7, 1α, 2α-Diacetoxy-8β-isobutanoyloxy-9α-benzoyloxy-15-β-(β-furancarbonyloxy)-4β, 6β-dihydroxy-β-dihydroagarofuran, is an eudesmane-type sesquiterpenoid located in the root bark of Pseudolarix kaempferi [1].
T83516	(Z)-2-Angeloyloxymethyl-2-butenoic
	(Z)-2-Angeloyloxymethyl-2-butenoic acid is a naturally occurring compound isolated from the roots of Anthriscus sylvestris Hoffm. [1].
TMA2415	4-Prenyloxyresveratrol	4'-Prenyloxyresveratrol	Others
	4'-Prenyloxyresveratrol is a natural product from Morus wittiorum.		Others
TN5683	Ethyl 4-(rhamnosyloxy)benzylcarbamate
	Ethyl 4-(rhamnosyloxy)benzylcarbamate is a natural product for research related to life sciences. The catalog number is TN5683 and the CAS number is 208346-80-9.
TN3303	8beta-(4-Hydroxytigloyloxy)ovatifolin		Others
	8beta-(4-Hydroxytigloyloxy)ovatifolin is a natural product for research related to life sciences. The catalog number is TN3303 and the CAS number is 554449-27-3.		Others
T40636	8-(3-Ethoxy-2-hydroxy-3-methylbutyloxy)psoralen
	8-(3-Ethoxy-2-hydroxy-3-methylbutyloxy)psoralen is a coumarin compound present in Heracleum pyrenaicum Lam.
TN5862	8-Hydroxy-9,10-diisobutyryloxythymol
	8-Hydroxy-9,10-diisobutyryloxythymol is a natural product for research related to life sciences. The catalog number is TN5862 and the CAS number is 22518-08-7.
TN4752	Perilloxin		COX
	Perilloxin possesses inhibitory activities against cyclooxygenase-1,with IC(50) values of 23.2 microM.		COX
TN1279	4''-methyloxy-Daidzin		Others
	4''-methyloxy-Daidzin is a natural product		Others
TN5375	1β,10β-Epoxy-6β-isobutyryloxy-9-oxofuranoeremophilane
	1beta,10beta-Epoxy-6beta-isobutyryloxy-9-oxofuranoeremophilane is a natural product from Ligularia fischeri.
TN3277	8-Geranyloxy-5,7-dimethoxycoumarin		Others
	8-Geranyloxy-5,7-dimethoxycoumarin is a natural product of Toddalia, Rutaceae. The catalog number is TN3277 and the CAS number is 1228175-65-2. 8-Geranyloxy-5,7-dimethoxycoumarin can be used as a reference standard.		Others
T83339	3β-(Acetyloxy)stigmast-5-en-7-one
	3β-(Acetyloxy)stigmast-5-en-7-one exhibits anti-complement activity [1].
TN5613	3α-Cinnamoyloxy-9β,17-dihydroxy-ent-kaur-15-en-19-oic acid	ent-3β-Cinnamoyloxy-9α,17-dihydroxykaur-15-en-19-oic acid
	3α-Cinnamoyloxy-9β,17-dihydroxy-ent-kaur-15-en-19-oic acid is a natural product for research related to life sciences. The catalog number is TN5613 and the CAS number is 2186648-60-0.
TN3300	8alpha-Tigloyloxyhirsutinolide 13-O-acetate		NADPH-oxidase , P450 , MAO
	8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has anti-cancer activity, it is active against both cancer cell...		NADPH-oxidase , P450 , MAO
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天然物製品

Pectolinarigenin

T6S0413

Synonym: Pectolinaringenin

Target: Others, Lipoxygenase, COX

Psoralidin

T3399

Synonym:

Target: Others, Estrogen/progestogen Receptor, Reactive Oxygen Species, Lipoxygenase, Gamma-secretase, Akt, COX, Antibacterial

4',5-Dihydroxyflavone

T8260

Synonym:

Target: Lipoxygenase, Glucosidase

Caffeic Acid

T2807

Synonym:

Target: Lipoxygenase, Endogenous Metabolite, TRP/TRPV Channel

Chebulagic acid

TQ0180

Synonym:

Target: SARS-CoV, Influenza Virus, Lipoxygenase, COX

Synonym: Caffeic Acid 3-Methyl Phenethyl Ester

Target: Lipoxygenase, COX

5-O-Demethylnobiletin

T5714

Synonym: 5-DEMETHYLNOBILETIN

Target: Leukotriene Receptor, Lipoxygenase

Nordihydroguaiaretic acid

TJS2190

Synonym: NDGA,Dihydronorguaiaretic Acid

Target: Antioxidant, Ferroptosis, Lipoxygenase, Autophagy

Aureusidin

TN5634

Synonym: Auresudidin,Auresidin

Target: Antioxidant, Reactive Oxygen Species, Lipoxygenase

S-(+)-Marmesin

T5759

Synonym: (+)-Marmesin,(S)-Marmesin,marmesin

Target: Lipoxygenase, COX

Xanthatin

T3S0153

Synonym:

Target: Apoptosis, VEGFR, Lipoxygenase, Wnt/beta-catenin, Antibacterial

β-Boswellic acid

TN1097

Synonym: Beta-boswellic acid

Target: Lipoxygenase, DNA/RNA Synthesis

Wedelolactone

T3384

Synonym: IKK Inhibitor II

Target: Apoptosis, NF-κB, Lipoxygenase, Caspase

3-O-Acetyl-11-hydroxy-beta-boswellic acid

TN1255

Synonym:

Target: Lipoxygenase

11-Keto-beta-boswellic acid

TN1182

Synonym: 11-Keto-beta-boswellic acid

Target: Leukotriene Receptor, NF-κB, Lipoxygenase

8-Geranyloxypsoralen

TN1343

Synonym:

Target: Anti-infection, P450, BACE

3,29-O-Dibenzoyloxykarounidiol

Target: DNA gyrase, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic

Benzoyloxypaeoniflorin

T4S1658

Synonym: Benzoyloxypeoniflorin

Target: NF-κB, Tyrosinase

Raloxifene hydrochloride

T1549

Synonym: LY156758 hydrochloride,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl

Target: Estrogen Receptor/ERR, Others, MAO, Estrogen/progestogen Receptor, Autophagy

Ciprofloxacin hydrochloride monohydrate

T8130

Synonym: Oftacilox,Ciprofloxacin hydrochloride hydrate,Bay-09867 hydrochloride monohydrate,Ceprimax,Ciloxan

Target: Antibacterial, Antibiotic

Danofloxacin mesylate

T1276

Synonym: CP 76136-27

Target: DNA/RNA Synthesis, Antibacterial, Antibiotic

7-Prenyloxycoumarin

T5744

Synonym: Nsc267697,7-O-Prenylumbelliferone

Target: Antifungal

Podofilox

T1121

Synonym: Podophyllotoxin,(+)-Shikonin

Target: Microtubule Associated, Topoisomerase

Levofloxacin

T6567

Synonym: Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin

Target: Topoisomerase, Antibacterial, Antibiotic

Tosufloxacin tosylate hydrate

T8046

Synonym: Tosufloxacin p-Toluenesulfonate Hydrate,A-61827 tosylate hydrate,T-3262 Tosylate Hydrate

Target: Others, Antibacterial, Antibiotic

Gatifloxacin hydrochloride

T8384

Synonym: AM-1155 (hydrochloride),BMS-206584 (hydrochloride),PD135432 (hydrochloride)

Target: Topoisomerase, Antibacterial, Antibiotic

3-(β-D-Glucopyranosyloxy)-1,6-dihydroxy-2-methyl-9,10-anthracenedione

T38658

Synonym:

Target:

8alpha-(2-Methylacryloyloxy)hirsutinolide

TN3295

Synonym:

Target: Others

8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol

T10197

Synonym: 8-9-epoxy-3-isobutyryloxy-10-2-methylbutanoyl-thymol

Decamethylcyclopentasiloxane

T21098

Synonym: Dekamethylcyklopentasiloxan,Cyclopentasiloxane, decamethyl-

Target:

Methyl 1,4-bisglucosyloxy-3-prenyl-2-naphthoate

TN1924

Synonym:

Target: Others

7-Geranyloxy-5-methoxycoumarin

TN3225

Synonym:

Target: Others

4α,8β-Dihydroxy-3α-(2-hydroxy-3-acetoxy-2-methylbutyryloxy)eudesm-7(11)-en-12,8α-olide

TN5399

Synonym:

Target:

1α, 2α-Diacetoxy-8β-isobutanoyloxy-9α-benzoyloxy-15-β-(β-furancarbonyloxy)-4β, 6β-dihydroxy-β-dihydroagarofuran

T83420

Synonym:

Target:

(Z)-2-Angeloyloxymethyl-2-butenoic

T83516

Synonym:

Target:

4-Prenyloxyresveratrol

TMA2415

Synonym: 4'-Prenyloxyresveratrol

Target: Others

Ethyl 4-(rhamnosyloxy)benzylcarbamate

TN5683

Synonym:

Target:

8beta-(4-Hydroxytigloyloxy)ovatifolin

TN3303

Synonym:

Target: Others

8-(3-Ethoxy-2-hydroxy-3-methylbutyloxy)psoralen

T40636

Synonym:

Target:

8-Hydroxy-9,10-diisobutyryloxythymol

4''-methyloxy-Daidzin

TN1279

Synonym:

Target: Others

1β,10β-Epoxy-6β-isobutyryloxy-9-oxofuranoeremophilane

TN5375

Synonym:

Target:

8-Geranyloxy-5,7-dimethoxycoumarin

TN3277

Synonym:

Target: Others

3β-(Acetyloxy)stigmast-5-en-7-one

T83339

Synonym:

Target:

3α-Cinnamoyloxy-9β,17-dihydroxy-ent-kaur-15-en-19-oic acid

TN5613

Synonym: ent-3β-Cinnamoyloxy-9α,17-dihydroxykaur-15-en-19-oic acid

Target:

8alpha-Tigloyloxyhirsutinolide 13-O-acetate

TN3300

Synonym:

Target: NADPH-oxidase, P450, MAO

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Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPK-01168	LOX-1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion...
TMPY-02490	LOX-1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LOX-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is P78380.
TMPH-03359	LOX Protein, Rat, Recombinant (His)	Rat	E. coli
	Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in t...
TMPY-04066	LOX-1 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	LOX-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.9 kDa and the accession number is O70156.
TMPY-03351	LOX-1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	LOX-1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.9 kDa and the accession number is G7PJT2.
TMPH-01968	LOX Protein, Human, Recombinant (His & MBP)	Human	Baculovirus Insect Cells
	LOX Protein, Human, Recombinant (His & MBP) is expressed in Baculovirus.
TMPY-03371	LOX-1 Protein, Rat, Recombinant (hFc)	Rat	HEK293 Cells
	LOX-1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 63.9 kDa and the accession number is O70156.
TMPH-02863	LOX Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus Insect Cells
	Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in t...
TMPY-03553	15 Lipoxygenase 2 Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	15 Lipoxygenase 2 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 76 kDa and the accession number is AAH35217.1.
TMPH-01969	LOX Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in t...
TMPY-03462	15 Lipoxygenase 2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	15 Lipoxygenase 2 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 103.7 kDa and the accession number is AAH35217.1.
TMPH-00955	ALOX12 Protein, Human, Recombinant (His)	Human	E. coli
	ALOX12 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPY-00203	LOXL2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein that belongs to the lysyl oxidase family. LOXL2 ...
TMPH-02774	LOXL4 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	May modulate the formation of a collagenous extracellular matrix. LOXL4 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 85.9 kDa and the acc...
TMPH-01628	LOXL1 Protein, Human, Recombinant	Human	E. coli
	Active on elastin and collagen substrates. LOXL1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 53.0 kDa and the accession number is Q08397.
TMPH-01629	LOXL1 Protein, Human, Recombinant (His)	Human	E. coli
	Active on elastin and collagen substrates.
TMPH-01630	LOXL3 Protein, Human, Recombinant (GST & His)	Human	E. coli
	LOXL3 Protein, Human, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 55.7 kDa and the accession number is P58215.
TMPH-00866	ADAMTS14 Protein, Human, Recombinant (His)	Human	E. coli
	Has aminoprocollagen type I processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity. Cleaves lysyl oxidase LOX at ...
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His)	Human	Baculovirus Insect Cells
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections,...