Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
説明 | PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo). |
ターゲット&IC50 | LRRK2:2.3 nM (IC50) |
In vivo | PFE-360 (4 mg/kg and 7.5 mg/kg, orally, BID, 10-12 weeks) treatment effectively reduces the LRRK2-pSer935/total LRRK2 ratio. It has no significant adverse effects[1]. |
別名 | PF-06685360 |
分子量 | 308.34 |
分子式 | C16H16N6O |
CAS No. | 1527475-61-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10.2 mg/mL (33.08 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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PFE-360 1527475-61-1 Autophagy LRRK2 PF 06685360 PFE 360 inhibit PFE360 Inhibitor Leucine-rich repeat kinase 2 PF-06685360 PF06685360 inhibitor