Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of 1 nM.
説明 | CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of 1 nM. |
ターゲット&IC50 | LRRK2 (wild-type):1.28 nM (IC50), LRRK2 (G2019S):1.85 nM (IC50) |
In vitro | CZC-54252 hydrochloride(1.6 nM) fully reverses G2019S LRRK2-induced human neuronal injury to wild-type levels. CZC-54252 hydrochloride inhibits the recombinant human wild-type LRRK2 with an IC50 ranging from 1 to 5 nM. CZC-54252 hydrochloride inhibits the G2019S mutant with an IC50 ranging from 2 to 7 nM in a TF-FRET assay[2]. |
分子量 | 541.45 |
分子式 | C22H26Cl2N6O4S |
CAS No. | 1784253-05-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (55.41 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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CZC-54252 hydrochloride 1784253-05-9 Autophagy LRRK2 CZC 54252 CZC54252 hydrochloride injury inhibit CZC54252 CZC-54252 neuronal Leucine-rich repeat kinase 2 neuroprotective CZC-54252 Hydrochloride Inhibitor CZC 54252 hydrochloride CZC 54252 Hydrochloride LRRK2-G2019S CZC54252 Hydrochloride inhibitor