Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
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1 mg | 在庫あり | ¥ 28,000 | |||
5 mg | 在庫あり | ¥ 64,000 | |||
10 mg | 在庫あり | ¥ 102,500 | |||
25 mg | 在庫あり | ¥ 170,000 | |||
50 mg | 在庫あり | ¥ 226,500 | |||
100 mg | 在庫あり | ¥ 319,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 67,500 |
説明 | PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM). |
ターゲット&IC50 | PI3Kγ:20 μM, PI4KIIIα:3 μM, PI4KIIIβ:3.6 nM, PI3Kα:10 μM, PI3KC2γ:1 μM, PI3Kδ:720 nM |
In vitro | The most potent of these molecules (PI4KIIIbeta-IN-10;compound 10) was screened over a panel of nine related lipid kinases and was >200 fold selective for PI4KIIIβ across all enzymes tested. Two of the most potent and selective molecules (compound 9+10) were also the most effective antiviral compounds in a cellular model of Hepatitis C virus replication, with the best balance of antiviral potency and low cellular toxicity. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~10 μM), and PI4KIIIα (~3 μM), and <20% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ[1]. |
分子量 | 475.58 |
分子式 | C22H25N3O5S2 |
CAS No. | 1881233-39-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (63.08 mM)
You can also refer to dose conversion for different animals. 詳細
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PI4KIIIbeta-IN-10 1881233-39-1 PI3K/Akt/mTOR signaling PI4K PI3K inhibit Phosphatidylinositol 4 kinases Inhibitor PI4 kinases PI4KIIIβ-IN-10 PI4KIIIbetaIN10 PI-4KIIIbeta-IN-10 PI4KIIIb-IN-10 PI4KIIIbeta IN 10 inhibitor