Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).
ターゲット&IC50 | PI3Kδ:145 nM |
In vitro | MSC2360844 inhibits B cell proliferation in a concentration-dependent manner with an IC50 of 48 nM. MSC2360844 blocks BCR- and TCR-mediated responses in lymphocytes and TLR-induced IFNα by pDC in human primary cells[1]. |
In vivo | in a murine SLE model,MSC2360844 ameliorates disease manifestations [1]. |
分子量 | 526.58 |
分子式 | C26H27FN4O5S |
CAS No. | 1305267-37-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (170.91 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MSC2360844 1305267-37-1 PI3K/Akt/mTOR signaling PI3K Phosphoinositide 3-kinase MSC 2360844 cells SLE-prone primary Inhibitor functions inhibit proliferation MSC-2360844 inhibitor