Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
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1 mg | 在庫あり | ¥ 20,500 | |||
5 mg | 在庫あり | ¥ 57,000 | |||
10 mg | 在庫あり | ¥ 85,000 | |||
25 mg | 在庫あり | ¥ 143,000 | |||
50 mg | 在庫あり | ¥ 203,500 | |||
100 mg | 在庫あり | ¥ 273,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 68,500 |
説明 | PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). . |
ターゲット&IC50 | PI3Kγ:1046 nM, PI4KIIIα:2.6 μM, PI4KIIIβ:7 nM, PI3Kα:2 μM, PI3KC2γ:1 μM, PI3Kδ:152 nM |
In vitro | PI4KIIIbeta-IN-9 (Compound 9) shows weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~2 μM), and PI4KIIIα (~2.6 μM) and <50% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ. PI4KIIIbeta-IN-9 forms a crescent shape that conforms to the active site of PI4KIIIβ. This molecule makes extensive contacts with PI4KIIIβ.PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively. |
分子量 | 487.59 |
分子式 | C23H25N3O5S2 |
CAS No. | 1429624-84-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.88 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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PI4KIIIbeta-IN-9 1429624-84-9 PI3K/Akt/mTOR signaling PI4K PI3K PI4 kinases inhibit Inhibitor Phosphatidylinositol 4 kinases PI4KIIIbetaIN9 PI4KIIIb-IN-9 Phosphoinositide 3-kinase PI4KIIIβ-IN-9 PI-4KIIIbeta-IN-9 PI4KIIIbeta IN 9 inhibitor