Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineurin.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 8,000 | |||
10 mg | 在庫あり | ¥ 12,500 | |||
25 mg | 在庫あり | ¥ 14,500 | |||
50 mg | 在庫あり | ¥ 16,500 | |||
100 mg | 在庫あり | ¥ 29,500 | |||
200 mg | 在庫あり | ¥ 43,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,500 |
説明 | Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineurin. |
In vitro | Pimecrolimus effectively alleviates allergic symptoms in a variety of (allergic) animals. Within the context of both the acute allergic dermatitis low-magnesium hairless rat model and the moderate allergic contact dermatitis mouse model, Pimecrolimus inhibits inflammatory responses and pruritic (itching) symptoms. |
In vivo | In mast cells, Pimecrolimus inhibits the transcription and synthesis of cytokines, while simultaneously promoting the release of 5-hydroxytryptamine and β-hexosaminidase. In T lymphocytes, Pimecrolimus suppresses activation by inhibiting phosphatase activity, thereby blocking T-cell activation. |
別名 | SDZ-ASM 981, ASM 981 |
分子量 | 810.45 |
分子式 | C43H68ClNO11 |
CAS No. | 137071-32-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 93 mg/mL (114.8 mM)
DMSO: 93 mg/mL (114.8 mM)
You can also refer to dose conversion for different animals. 詳細
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Pimecrolimus 137071-32-0 Others mast cells T-cells SDZ-ASM 981 ASM-981 ASM 981 atopic dermatitis oral erosive lichen planus Phosphatase Inhibitor inhibit SDZ-ASM981 anti-inflammatory orally active inflammatory skin diseases SDZ-ASM-981 ASM981 inhibitor