Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis.
説明 | Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis. |
In vitro | Piperazine erastin is affected similarly by cell death modulators as erastin and displays a distinct pattern from other non-FIN lethal compounds. Piperazine erastin is a more effective analog of erastin which is more water-soluble (0.086 mM for erastin versus 1.4 mM for piperazine erastin) and more metabolically stable [1]. |
In vivo | A significant delay in tumor growth is observed in the piperazine erastin-treated group compared to the vehicle-treated group, in the xenograft mouse model. Ptgs2 is upregulated in mouse liver with piperazine erastin (10 or 60 mg/kg) administration[1]. |
分子量 | 645.19 |
分子式 | C35H41ClN6O4 |
CAS No. | 1538593-71-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.33 mg/mL (51.66 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Piperazine Erastin 1538593-71-3 Apoptosis Ferroptosis Inhibitor inhibitor inhibit