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Search Results for " Ferroptosis "

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天然化合物

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カタログ番号	製品名	別名	ターゲット
T72403	Ferroptosis inducer-1
	Ferroptosis inducer-1 is a Ferroptosis inducer with antitumor potential .
T82408	Ferroptosis-IN-3		Ferroptosis
	Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM). It exhibits radical scavenging abilities against DPPH and ABTS...		Ferroptosis
T79945	Ferroptosis-IN-1		Ferroptosis
	Ferroptosis-IN-1, a diterpene derived from A. campylantha, functions as a ferroptosis inhibitor with an EC50 of 10 μM and is utilized in the study of neuroinflammatory diseases [1].		Ferroptosis
T2376	Liproxstatin-1		Ferroptosis
	Liproxstatin-1 is a potent and selective inhibitor of iron death (IC50=22 nM). Liproxstatin-1 protects cells from iron death induced by iron death inducers (e.g., Erastin, RSL3).		Ferroptosis
T1765	Erastin		Ferroptosis , VDAC
	Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner. Erastin has anti-tumor activity and acts selectively on tumor cells with RAS-carcinogenic mutations. The product...		Ferroptosis , VDAC
T1710	Trolox		Apoptosis , Antioxidant , Ferroptosis , Reactive Oxygen Species
	Trolox is a vitamin E analogue, used in reducing oxidative stress or damage.
T5343	UAMC-3203	UAMC 3203,UAMC3203	Ferroptosis
	UAMC-3203 is a potent and selective Ferroptosis inhibitor (IC50: 12 nM).		Ferroptosis
T4360	ML385		Others , Ferroptosis , Nrf2
	ML385 is an NRF2 inhibitor (IC50=1.9 μM) with novelty and specificity. ML385 has anti-inflammatory activity by modulating anti-oxidative stress through the inhibition of NRF2. ML385 also exhibits anti-tumor activity.		Others , Ferroptosis , Nrf2
T4066	FIN56		Ferroptosis
	FIN56 is a specific inducer of ferroptosis.		Ferroptosis
T37314	JKE-1674		GPX
	JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.		GPX
T1482	Ciclopirox	HOE296b	ATPase , Ferroptosis , Antibacterial , Autophagy , Antifungal
	Ciclopirox (HOE296b) exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. Ciclopirox is a synthetic, broad-spect...
T6243	U-73122	U73122	Phospholipase , Ferroptosis , Lipoxygenase
	U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.		Phospholipase , Ferroptosis , Lipoxygenase
T4309	CIL56	CA3	Ferroptosis , ROS
	CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyuns...		Ferroptosis , ROS
T8970	ML162		Ferroptosis , GPX , Glutathione Peroxidase
	ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively)		Ferroptosis , GPX , Glutathione Peroxidase
T8662	UAMC-3203 hydrochloride		Ferroptosis
	UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM.		Ferroptosis
T9073	SRS16-86		Ferroptosis
	SRS16-86 is a novel third-generation ferrostatin, is an inhibitor of ferroptosis.		Ferroptosis
T19467	NADPH tetracyclohexanamine	NADPH (tetracyclohexanamine)	Ferroptosis
	NADPH tetracyclohexanamine (NADPH (tetracyclohexanamine)) is a cofactor and biological reducing agent.		Ferroptosis
T7092	NADPH tetrasodium salt		Others , Ferroptosis , Endogenous Metabolite
	NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate, which acts as an electron donor in a variety of biological reactions. NADPH tetrasodium salt is also an end...		Others , Ferroptosis , Endogenous Metabolite
T1787	Levobupivacaine		Sodium Channel
	Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZ...		Sodium Channel
T11631	IFSP1		Ferroptosis
	iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RS...		Ferroptosis
T1564	Cisplatin	cis-Diaminodichloroplatinum,CDDP	DNA Alkylator/Crosslinker , Ferroptosis , DNA/RNA Synthesis , Autophagy
	Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also activates iron death and induces autophagy.
T1565	Deferiprone	Deferidone,CP20	Others , HCV Protease , Ferroptosis , UGT
	Deferiprone (Deferidone) is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity.		Others , HCV Protease , Ferroptosis , UGT
T0935	Butylated hydroxytoluene	BHT FCC/NF	Antioxidant , Ferroptosis
	Butylated hydroxytoluene (BHT FCC/NF) is an antioxidant widely used in food, cosmetics and industrial liquids. It is a ferroptosis inhibitor.		Antioxidant , Ferroptosis
T6099	Setanaxib	GKT137831	NADPH-oxidase , Ferroptosis , NADPH
	Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.		NADPH-oxidase , Ferroptosis , NADPH
T2488	BAY 87-2243		Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF
	BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).		Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF
T4414	Eprenetapopt	APR-246,PRIMA-1Met	Apoptosis , Others , Ferroptosis , p53 , Autophagy
	Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of c...		Apoptosis , Others , Ferroptosis , p53 , Autophagy
T8922	SRS11-92	AA9	Ferroptosis
	SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1		Ferroptosis
T6821	Dp44mT		Apoptosis , Others , Ferroptosis
	Dp44mT, a effective iron chelator, has selective antitumor activity.		Apoptosis , Others , Ferroptosis
T0191	Linagliptin	BI 1356	Ferroptosis , Proteasome , DPP-4 , Autophagy
	Linagliptin (BI 1356) is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.		Ferroptosis , Proteasome , DPP-4 , Autophagy
T6192	Alogliptin	SYR-322	Ferroptosis , Proteasome , DPP-4
	Alogliptin (SYR-322)(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9.		Ferroptosis , Proteasome , DPP-4
T1934	Bay 11-7085	BAY 11-7083	Apoptosis , IκB/IKK , Ferroptosis , NF-κB
	Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).		Apoptosis , IκB/IKK , Ferroptosis , NF-κB
T8375	ML-210	CID 49766530	Ferroptosis , GPX , Glutathione Peroxidase , Ras
	ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity		Ferroptosis , GPX , Glutathione Peroxidase , Ras
T5364	TBHQ	tert-Butylhydroquinone	Apoptosis , ERK , Others , Ferroptosis , Nrf2 , Autophagy
	TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.		Apoptosis , ERK , Others , Ferroptosis , Nrf2 , Autophagy
T0477	Zileuton	Abbott 64077,A 64077	Ferroptosis , Lipoxygenase , COX
	Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; ca...		Ferroptosis , Lipoxygenase , COX
T1114	Ciclopirox olamine	Ciclopirox ethanolamine	ATPase , Others , Ferroptosis , Antibacterial , Antifungal
	Ciclopirox olamine is a broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities.
T3646	RSL3	RSL3 1S,1S,3R-RSL3	Ferroptosis , GPX , Glutathione Peroxidase
	RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that is selective for tumor cells carrying oncogenic RAS.		Ferroptosis , GPX , Glutathione Peroxidase
T6500	Ferrostatin-1	Ferrostatin 1,Ferrostatin-1 (Fer-1)	Ferroptosis , Antifungal
	Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of iron death. Ferrostatin-1 potently inhibits Erastin-induced iron death in HT-1080 cells with an EC50 of 60 nM. Ferrostatin-1 also exhibits antioxidant and anti...		Ferroptosis , Antifungal
T1457	Deferasirox	ICL 670,CGP-72670	Others , Ferroptosis , Antibacterial
	Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.		Others , Ferroptosis , Antibacterial
T0907	Sulfasalazine	NSC 667219,Azulfidine	Apoptosis , Ferroptosis , NF-κB , COX , Antibacterial , Antibiotic , Autophagy
	Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
T1847	Necrostatin-1	Nec-1,Necrostatin 1	Indoleamine 2,3-Dioxygenase (IDO) , Ferroptosis , Autophagy , RIP kinase
	Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin-1 also inhibits IDO.
T3109	SP600125	1PMV,JNK Inhibitor II,Nsc75890,Pyrazolanthrone	Apoptosis , Ferroptosis , Trk receptor , JNK , Aurora Kinase , Autophagy
	SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive properties. SP600125 inhibits autophagy and induces apoptosis.
T7530	PD146176	NSC168807	Ferroptosis , Lipoxygenase , Autophagy
	PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology...		Ferroptosis , Lipoxygenase , Autophagy
T2515	Roxadustat	ASP1517,FG-4592	Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF
	Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.		Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF
T0214	Pioglitazone	U 72107	Ferroptosis , PPAR
	Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare instances of acute liver injury.		Ferroptosis , PPAR
T0093L	Sorafenib	Bay 43-9006	Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy
	Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. Sorafenib has antitumor activity...
T1885	Siramesine hydrochloride	Lu 28-179 hydrochloride	Ferroptosis , Sigma receptor , lysosomal autophagy
	Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo.		Ferroptosis , Sigma receptor , lysosomal autophagy
T27061	CP-24879 hydrochloride	CP-24879 HCl	Others
	CP-24879 hydrochloride (CP-24879 HCl), a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic an...		Others
T0078	Lapatinib	GSK572016,GW572016	EGFR , Ferroptosis , Autophagy
	Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity. Lapatinib has antitumor activity and can be used to treat advanced or metastatic breast cancer with HER2 overexpression.		EGFR , Ferroptosis , Autophagy
T3170	Troglitazone	CS-045,Romozin,Rezulin,Romglizone,Noscal,Prelay	Apoptosis , Ferroptosis , PPAR , Autophagy
	Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.		Apoptosis , Ferroptosis , PPAR , Autophagy
T6954	PRIMA-1	2,2-Bis(hydroxymethyl)-3-quinuclidinone,NSC-281668,PRIMA 1	Apoptosis , Others , Ferroptosis , Autophagy
	PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.		Apoptosis , Others , Ferroptosis , Autophagy

Compounds

Ferroptosis inducer-1

Target: Ferroptosis

Ferroptosis-IN-1

T79945

Synonym:

Target: Ferroptosis

Liproxstatin-1

T2376

Synonym:

Target: Ferroptosis

Erastin

T1765

Synonym:

Target: Ferroptosis, VDAC

Trolox

T1710

Synonym:

Target: Apoptosis, Antioxidant, Ferroptosis, Reactive Oxygen Species

UAMC-3203

T5343

Synonym: UAMC 3203,UAMC3203

Target: Ferroptosis

ML385

T4360

Synonym:

Target: Others, Ferroptosis, Nrf2

FIN56

T4066

Synonym:

Target: Ferroptosis

Target: ATPase, Ferroptosis, Antibacterial, Autophagy, Antifungal

U-73122

T6243

Synonym: U73122

Target: Phospholipase, Ferroptosis, Lipoxygenase

CIL56

T4309

Synonym: CA3

Target: Ferroptosis, ROS

ML162

T8970

Synonym:

Target: Ferroptosis, GPX, Glutathione Peroxidase

UAMC-3203 hydrochloride

T8662

Synonym:

Target: Ferroptosis

SRS16-86

T9073

Synonym:

Target: Ferroptosis

NADPH tetracyclohexanamine

T19467

Synonym: NADPH (tetracyclohexanamine)

Target: Ferroptosis

NADPH tetrasodium salt

T7092

Synonym:

Target: Others, Ferroptosis, Endogenous Metabolite

Levobupivacaine

T1787

Synonym:

Target: Sodium Channel

iFSP1

T11631

Synonym:

Target: Ferroptosis

Cisplatin

T1564

Synonym: cis-Diaminodichloroplatinum,CDDP

Target: DNA Alkylator/Crosslinker, Ferroptosis, DNA/RNA Synthesis, Autophagy

Deferiprone

T1565

Synonym: Deferidone,CP20

Target: Others, HCV Protease, Ferroptosis, UGT

Butylated hydroxytoluene

T0935

Synonym: BHT FCC/NF

Target: Antioxidant, Ferroptosis

Setanaxib

T6099

Synonym: GKT137831

Target: NADPH-oxidase, Ferroptosis, NADPH

BAY 87-2243

T2488

Synonym:

Target: Ferroptosis, HIF/HIF Prolyl-Hydroxylase, HIF

Eprenetapopt

T4414

Synonym: APR-246,PRIMA-1Met

Target: Apoptosis, Others, Ferroptosis, p53, Autophagy

SRS11-92

T8922

Synonym: AA9

Target: Ferroptosis

Dp44mT

T6821

Synonym:

Target: Apoptosis, Others, Ferroptosis

Linagliptin

T0191

Synonym: BI 1356

Target: Ferroptosis, Proteasome, DPP-4, Autophagy

Alogliptin

T6192

Synonym: SYR-322

Target: Ferroptosis, Proteasome, DPP-4

Bay 11-7085

T1934

Synonym: BAY 11-7083

Target: Apoptosis, IκB/IKK, Ferroptosis, NF-κB

ML-210

T8375

Synonym: CID 49766530

Target: Ferroptosis, GPX, Glutathione Peroxidase, Ras

TBHQ

T5364

Synonym: tert-Butylhydroquinone

Target: Apoptosis, ERK, Others, Ferroptosis, Nrf2, Autophagy

Zileuton

T0477

Synonym: Abbott 64077,A 64077

Target: Ferroptosis, Lipoxygenase, COX

Ciclopirox olamine

T1114

Synonym: Ciclopirox ethanolamine

Target: ATPase, Others, Ferroptosis, Antibacterial, Antifungal

RSL3

T3646

Synonym: RSL3 1S,1S,3R-RSL3

Target: Ferroptosis, GPX, Glutathione Peroxidase

Ferrostatin-1

T6500

Synonym: Ferrostatin 1,Ferrostatin-1 (Fer-1)

Target: Ferroptosis, Antifungal

Deferasirox

T1457

Synonym: ICL 670,CGP-72670

Target: Others, Ferroptosis, Antibacterial

Sulfasalazine

T0907

Synonym: NSC 667219,Azulfidine

Target: Apoptosis, Ferroptosis, NF-κB, COX, Antibacterial, Antibiotic, Autophagy

Necrostatin-1

T1847

Synonym: Nec-1,Necrostatin 1

Target: Indoleamine 2,3-Dioxygenase (IDO), Ferroptosis, Autophagy, RIP kinase

SP600125

T3109

Synonym: 1PMV,JNK Inhibitor II,Nsc75890,Pyrazolanthrone

Target: Apoptosis, Ferroptosis, Trk receptor, JNK, Aurora Kinase, Autophagy

PD146176

T7530

Synonym: NSC168807

Target: Ferroptosis, Lipoxygenase, Autophagy

Roxadustat

T2515

Synonym: ASP1517,FG-4592

Target: Ferroptosis, HIF/HIF Prolyl-Hydroxylase, HIF

Pioglitazone

T0214

Synonym: U 72107

Target: Ferroptosis, PPAR

Sorafenib

T0093L

Synonym: Bay 43-9006

Target: Apoptosis, Raf, VEGFR, FLT, Ferroptosis, PDGFR, c-Kit, Autophagy

Siramesine hydrochloride

T1885

Synonym: Lu 28-179 hydrochloride

Target: Ferroptosis, Sigma receptor, lysosomal autophagy

CP-24879 hydrochloride

T27061

Synonym: CP-24879 HCl

Target: Others

Lapatinib

T0078

Synonym: GSK572016,GW572016

Target: EGFR, Ferroptosis, Autophagy

Troglitazone

T3170

Synonym: CS-045,Romozin,Rezulin,Romglizone,Noscal,Prelay

Target: Apoptosis, Ferroptosis, PPAR, Autophagy

PRIMA-1

T6954

Synonym: 2,2-Bis(hydroxymethyl)-3-quinuclidinone,NSC-281668,PRIMA 1

Target: Apoptosis, Others, Ferroptosis, Autophagy

カタログ番号	製品名	別名	ターゲット
T3S1447	Arteannuin B		SARS-CoV , Ferroptosis
	1. Arteannuin B has potent antimalarial activity.		SARS-CoV , Ferroptosis
T2887	Trigonelline	Trigenolline	Apoptosis , Others , Ferroptosis , Endogenous Metabolite
	Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.		Apoptosis , Others , Ferroptosis , Endogenous Metabolite
T6468	D-glutamine		Mitophagy , Ferroptosis , Endogenous Metabolite , GluR , Autophagy
	D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.
T5515	Hemin	Hemin chloride	Mitophagy , Ferroptosis , Autophagy
	Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer. Hemin has therapeutic activity in porphyrias by reducing heme deficiency in patients, thereby inhibiting δ-aminolevulini...		Mitophagy , Ferroptosis , Autophagy
T5687	WITHAFERIN A		Ferroptosis , NF-κB
	WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or cancer.		Ferroptosis , NF-κB
T2858	Baicalein	5,6,7-Trihydroxyflavone	Ferroptosis , Influenza Virus , ROS , Xanthine Oxidase
	Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor.		Ferroptosis , Influenza Virus , ROS , Xanthine Oxidase
T0433	Artesunate	WR-256283	Virus Protease , Ferroptosis , STAT , Parasite
	Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is on the World Heal...		Virus Protease , Ferroptosis , STAT , Parasite
T1207	Lovastatin	MK-803,Mevinolin	Ferroptosis , HMG-CoA Reductase , Autophagy
	Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.		Ferroptosis , HMG-CoA Reductase , Autophagy
TJS2190	Nordihydroguaiaretic acid	NDGA,Dihydronorguaiaretic Acid	Antioxidant , Ferroptosis , Lipoxygenase , Autophagy
	Nordihydroguaiaretic acid (NDGA) (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibito...		Antioxidant , Ferroptosis , Lipoxygenase , Autophagy
T2O2733	L-Cystine	Cystine Acid,cystine	Antioxidant , Ferroptosis , Endogenous Metabolite
	L-Cystine (Cystine Acid) is not considered one of the 20 amino acids, L-Cystine (Cystine Acid) is a sulfur-containing derivative obtained from oxidation of cysteine amino acid thiol side chains. It functions as an antiox...		Antioxidant , Ferroptosis , Endogenous Metabolite
T6947	Piperlongumine	PPLGM,Piplartine	Apoptosis , ERK , Ferroptosis , Reactive Oxygen Species , ROS , Antibacterial , Autophagy
	Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).
T1922	Pseudolaric Acid B		Apoptosis , p38 MAPK , Ferroptosis , HBV , Autophagy , Antifungal
	Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.
THS1455	DihydroarteMisinic acid	Dihydro-Artmisinic Acid	Ferroptosis , Parasite
	DihydroarteMisinic acid (Dihydro-Artmisinic Acid) is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinal herb that is widely used to treat Malaria.		Ferroptosis , Parasite
T2796	Coenzyme Q10	Ubiquinone-10,CoQ10	Ferroptosis , Reactive Oxygen Species , Endogenous Metabolite
	Coenzyme Q10 (CoQ10) (ubiquinone) is a naturally occurring compound, acting as the electron carrier in the mitochondrial respiratory chain.
T2856	(-)-Epicatechin	L-Epicatechin,Epicatechin,(-)-Epicatechol	Ferroptosis , COX , Endogenous Metabolite
	(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.		Ferroptosis , COX , Endogenous Metabolite
T0877	Gallic acid	3,4,5-Trihydroxybenzoic acid,Gallate,Benzoic acid	Apoptosis , Ferroptosis , Reactive Oxygen Species , ROS , COX , Endogenous Metabolite
	Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
TJS1159	Chrysosplenetin	Chrysosptertin B	P450 , Ferroptosis , P-gp
	Chrysosplenetin is a metabolic inhibitor of artemisinin.		P450 , Ferroptosis , P-gp
T1644	Dopamine hydrochloride	Dopamine HCl,ASL279	Ferroptosis , Dopamine Receptor , 5-HT Receptor , Endogenous Metabolite
	Dopamine hydrochloride (ASL279) is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine hydrochloride binds to alpha-1- and b...
T0326L	L-Glutamine	L-Glutamic acid 5-amide	Ferroptosis , Endogenous Metabolite , GluR
	L-Glutamine (L-Glutamic acid 5-amide) , a non-essential amino acid, is synthesized from glutamic acid and ammonia.		Ferroptosis , Endogenous Metabolite , GluR
T1297	Eugenol	4-Allylguaiacol,Allylguaiacol,4-Allyl-2-methoxyphenol,Eugenic acid	Apoptosis , Ferroptosis , Reactive Oxygen Species , Antibacterial , Parasite
	Eugenol (Allylguaiacol) is a Standardized Chemical Allergen. The physiologic effect of eugenol is by means of Increased Histamine Release and Cell-mediated Immunity.
T0875	Acetylcysteine	N-Acetyl-L-cysteine,LNAC,NAC	Apoptosis , TNF , Ferroptosis , Influenza Virus , Reactive Oxygen Species , ROS , Endogenous Metabolite
	Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus thickness, and has anti-influenza viral activity.
T20819	Ammonium iron(III) citrate	Ferric ammonium citrate	Others , Ferroptosis
	Ammonium iron(III) citrate (Ferric ammonium citrate) is a physiological form of non-ferritin-bound iron that causes intracellular iron overload leading to cellular iron death and enhances protein production.		Others , Ferroptosis
T0392	Artemisinin	Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,Artemisinine	HCV Protease , Ferroptosis , Akt , Parasite
	Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organisms, including chloroquine-resistant Plasmodium ...		HCV Protease , Ferroptosis , Akt , Parasite
T0326	DL-Glutamine	Glutamin,DL-Gl,(±)-Glutamine,2-amino-4-carbamoylbutanoic acid	Ferroptosis , Amino Acids and Derivatives , Endogenous Metabolite
	DL-Glutamine (2-amino-4-carbamoylbutanoic acid), a non-essential amino acid, exists abundantly throughout the body and is participated in many metabolic processes. It is synthesized from glutamic acid and ammonia, and is...
T5679	(E)-Ferulic acid	trans-Ferulic acid,(E)-Coniferic acid	BCL , Ferroptosis , Wnt/beta-catenin , Endogenous Metabolite
	(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pr...
T0672	Pravastatin sodium	CS-514 Sodium,CS-514 (sodium)	Ferroptosis , HMG-CoA Reductase , Autophagy
	Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.		Ferroptosis , HMG-CoA Reductase , Autophagy
TMA2394	DL-alpha-Tocopherol	DL-α-Tocopherol,Alpha-Tochopherol,Ephanyl	Antioxidant , Ferroptosis
	DL-alpha-Tocopherol (Ephanyl) is a synthetic vitamin E that protects skin fibroblasts from the cytotoxic effects of UV light and has antioxidant properties.		Antioxidant , Ferroptosis
T0687	Simvastatin	MK-0733,MK 733	Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy
	Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovasc...
T1516	Curcumin	Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow	Mitophagy , Epigenetic Reader Domain , Ferroptosis , Influenza Virus , Nrf2 , Histone Acetyltransferase , HDAC , Autophagy
	Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, ant...
T2A2497	L-Glutamic acid	(S)-Glutamic acid,glutamic acid,(+)-L-Glutamic acid,Aciglut,glutacid,Glutaminol	Apoptosis , Ferroptosis , Endogenous Metabolite , iGluR
	L-Glutamic acid (Glutaminol) acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.		Apoptosis , Ferroptosis , Endogenous Metabolite , iGluR
T2870	Matrine	Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine	Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
	Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.		Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
T6871	L-Glutamic acid monosodium salt	Monosodium glutamate,Glutacyl,Glutavene,Ajinomoto,MSG	Apoptosis , Ferroptosis , GluR , iGluR
	L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.		Apoptosis , Ferroptosis , GluR , iGluR
T1085	L-Glutathione reduced	GSH,Isethion,Glutathione,γ-L-Glutamyl-L-cysteinyl-glycine,Glutathion,Tathion	Ferroptosis , Reactive Oxygen Species , Endogenous Metabolite , Glutathione reductase
	L-Glutathione reduced (Glutathione) is a naturally occurring tripeptide found in cells as an endogenous antioxidant that scavenges oxygen free radicals. L-Glutathione reduced is a cofactor for certain enzymes and is invo...
T1648	α-Vitamin E	Dexrabeprazole Sodium,Vitamin E,Alpha-Tocopherol,D-α-Tocopherol,5,7,8-Trimethyltocol,(+)-alpha-Tocopherol	Others , Ferroptosis , Influenza Virus , Reactive Oxygen Species , Endogenous Metabolite , Antibacterial , PKC , GST
	α-Vitamin E (Dexrabeprazole Sodium) is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
TN5770	Gingerenone A		Nrf2
	Gingerenone A is an effective Nrf2-Gpx4 activator. It is a small molecule compound isolated from ginger. It has anti-cancer activity, can prolong the cell cycle of cancer cells, and can inhibit dextran sodium sulfate (DS...		Nrf2
T79940	Moracin N		Glutathione Peroxidase
	Moracin N, a ferroptosis inhibitor derived from mulberry leaves, exhibits neuroprotective activity by mitigating oxidative stress [1].		Glutathione Peroxidase

天然物製品

Arteannuin B

T3S1447

Synonym:

Target: SARS-CoV, Ferroptosis

Trigonelline

T2887

Synonym: Trigenolline

Target: Apoptosis, Others, Ferroptosis, Endogenous Metabolite

D-glutamine

T6468

Synonym:

Target: Mitophagy, Ferroptosis, Endogenous Metabolite, GluR, Autophagy

Hemin

T5515

Synonym: Hemin chloride

Target: Mitophagy, Ferroptosis, Autophagy

WITHAFERIN A

T5687

Synonym:

Target: Ferroptosis, NF-κB

Baicalein

T2858

Synonym: 5,6,7-Trihydroxyflavone

Target: Ferroptosis, Influenza Virus, ROS, Xanthine Oxidase

Artesunate

T0433

Synonym: WR-256283

Target: Virus Protease, Ferroptosis, STAT, Parasite

Lovastatin

T1207

Synonym: MK-803,Mevinolin

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

Nordihydroguaiaretic acid

TJS2190

Synonym: NDGA,Dihydronorguaiaretic Acid

Target: Antioxidant, Ferroptosis, Lipoxygenase, Autophagy

L-Cystine

T2O2733

Synonym: Cystine Acid,cystine

Target: Antioxidant, Ferroptosis, Endogenous Metabolite

Piperlongumine

T6947

Synonym: PPLGM,Piplartine

Target: Apoptosis, ERK, Ferroptosis, Reactive Oxygen Species, ROS, Antibacterial, Autophagy

Pseudolaric Acid B

T1922

Synonym:

Target: Apoptosis, p38 MAPK, Ferroptosis, HBV, Autophagy, Antifungal

DihydroarteMisinic acid

THS1455

Synonym: Dihydro-Artmisinic Acid

Target: Ferroptosis, Parasite

Coenzyme Q10

T2796

Synonym: Ubiquinone-10,CoQ10

Target: Ferroptosis, Reactive Oxygen Species, Endogenous Metabolite

(-)-Epicatechin

T2856

Synonym: L-Epicatechin,Epicatechin,(-)-Epicatechol

Target: Ferroptosis, COX, Endogenous Metabolite

Gallic acid

T0877

Synonym: 3,4,5-Trihydroxybenzoic acid,Gallate,Benzoic acid

Target: Apoptosis, Ferroptosis, Reactive Oxygen Species, ROS, COX, Endogenous Metabolite

Chrysosplenetin

TJS1159

Synonym: Chrysosptertin B

Target: P450, Ferroptosis, P-gp

Dopamine hydrochloride

T1644

Synonym: Dopamine HCl,ASL279

Target: Ferroptosis, Dopamine Receptor, 5-HT Receptor, Endogenous Metabolite

L-Glutamine

T0326L

Synonym: L-Glutamic acid 5-amide

Target: Ferroptosis, Endogenous Metabolite, GluR

Eugenol

T1297

Synonym: 4-Allylguaiacol,Allylguaiacol,4-Allyl-2-methoxyphenol,Eugenic acid

Target: Apoptosis, Ferroptosis, Reactive Oxygen Species, Antibacterial, Parasite

Acetylcysteine

T0875

Synonym: N-Acetyl-L-cysteine,LNAC,NAC

Target: Apoptosis, TNF, Ferroptosis, Influenza Virus, Reactive Oxygen Species, ROS, Endogenous Metabolite

Ammonium iron(III) citrate

T20819

Synonym: Ferric ammonium citrate

Target: Others, Ferroptosis

Artemisinin

T0392

Synonym: Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,Artemisinine

Target: HCV Protease, Ferroptosis, Akt, Parasite

DL-Glutamine

T0326

Synonym: Glutamin,DL-Gl,(±)-Glutamine,2-amino-4-carbamoylbutanoic acid

Target: Ferroptosis, Amino Acids and Derivatives, Endogenous Metabolite

(E)-Ferulic acid

T5679

Synonym: trans-Ferulic acid,(E)-Coniferic acid

Target: BCL, Ferroptosis, Wnt/beta-catenin, Endogenous Metabolite

Pravastatin sodium

T0672

Synonym: CS-514 Sodium,CS-514 (sodium)

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

DL-alpha-Tocopherol

TMA2394

Synonym: DL-α-Tocopherol,Alpha-Tochopherol,Ephanyl

Target: Antioxidant, Ferroptosis

Simvastatin

T0687

Synonym: MK-0733,MK 733

Target: Apoptosis, Mitophagy, Ferroptosis, HMG-CoA Reductase, Autophagy

Curcumin

T1516

Synonym: Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow

Target: Mitophagy, Epigenetic Reader Domain, Ferroptosis, Influenza Virus, Nrf2, Histone Acetyltransferase, HDAC, Autophagy

L-Glutamic acid

T2A2497

Synonym: (S)-Glutamic acid,glutamic acid,(+)-L-Glutamic acid,Aciglut,glutacid,Glutaminol

Target: Apoptosis, Ferroptosis, Endogenous Metabolite, iGluR

Matrine

T2870

Synonym: Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine

Target: Mitophagy, Ferroptosis, Opioid Receptor, Autophagy

L-Glutamic acid monosodium salt

T6871

Synonym: Monosodium glutamate,Glutacyl,Glutavene,Ajinomoto,MSG

Target: Apoptosis, Ferroptosis, GluR, iGluR

L-Glutathione reduced

T1085

Synonym: GSH,Isethion,Glutathione,γ-L-Glutamyl-L-cysteinyl-glycine,Glutathion,Tathion

Target: Ferroptosis, Reactive Oxygen Species, Endogenous Metabolite, Glutathione reductase

α-Vitamin E

T1648

Synonym: Dexrabeprazole Sodium,Vitamin E,Alpha-Tocopherol,D-α-Tocopherol,5,7,8-Trimethyltocol,(+)-alpha-Tocopherol

Target: Others, Ferroptosis, Influenza Virus, Reactive Oxygen Species, Endogenous Metabolite, Antibacterial, PKC, GST

Target: Glutathione Peroxidase

カタログ番号	製品名
L8700	Ferroptosis Compound Library	779 compounds
	A unique collection of 779 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study；
L8710	Cuproptosis Compound Library	400 compounds
	TargetMol’s Cuproptosis Compound Library is a collection of 400 compounds related to copper-dependent death that can be used to study its mechanism and related diseases.

ライブラリー

Ferroptosis Compound Library

L8700

Compounds: 779

Cuproptosis Compound Library

L8710

Compounds: 400