Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 12,000 | |||
10 mg | 在庫あり | ¥ 20,500 | |||
25 mg | 在庫あり | ¥ 35,500 | |||
50 mg | 在庫あり | ¥ 55,000 | |||
100 mg | 在庫あり | ¥ 91,500 |
説明 | Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction. |
植物由来 |
分子量 | 855.02 |
分子式 | C44H70O16 |
CAS No. | 50773-41-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 117 mM
You can also refer to dose conversion for different animals. 詳細
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Polyphyllin I 50773-41-6 Apoptosis Autophagy Cytoskeletal Signaling MAPK PI3K/Akt/mTOR signaling mTOR PDK JNK Akt PDK-1 Protein kinase B PKB inhibit Mammalian target of Rapamycin Inhibitor inhibitor