Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition of Wnt/β-catenin pathway in some types of cancer.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 7,500 | |||
10 mg | 在庫あり | ¥ 11,000 | |||
25 mg | 在庫あり | ¥ 15,000 | |||
50 mg | 在庫あり | ¥ 18,500 | |||
100 mg | 在庫あり | ¥ 27,500 |
説明 | Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition of Wnt/β-catenin pathway in some types of cancer. |
In vitro | Pyrvinium pamoate treatment repressed the phosphorylation of GSK3β at S9 which might be mediated by AKT, and decreased the protein levels of β-catenin and its downstream targets (c-Myc, cyclin D1). Pyrvinium pamoate remarkably inhibited cell viability and colony formation ability. Treatment with pyrvinium pamoate induced intrinsic pathway-dependent apoptosis accompanied with a decline of anti-apoptotic XIAP and Survivin, and an overt increase of pro-apoptotic Bax. In addition, pyrvinium pamoate significantly inhibited the migration and invasion in vitro[1]. |
別名 | Pyrvinium embonate |
分子量 | 575.7 |
分子式 | C26H28N3 . 1/2 C23H14O6 |
CAS No. | 3546-41-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12 mg/mL (20.84 mM)
You can also refer to dose conversion for different animals. 詳細
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Pyrvinium pamoate 3546-41-6 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin inhibit Pyrvinium Inhibitor Pyrvinium embonate Wnt inhibitor