Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 12,500 |
2 mg | 在庫あり | ¥ 18,000 |
5 mg | 在庫あり | ¥ 29,000 |
10 mg | 在庫あり | ¥ 52,000 |
25 mg | 在庫あり | ¥ 80,000 |
50 mg | お問い合わせ | ¥ 103,500 |
100 mg | お問い合わせ | ¥ 146,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 32,500 |
説明 | Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. |
ターゲット&IC50 | HDAC1:0.11 nM |
In vitro | Quisinostat exerts broad-spectrum antiproliferative activity against a wide panel of cancer cell lines including lung, colon, breast, prostate, and ovarian cell lines at nanomolar concentrations. JNJ-26481585 shows activity toward all HDAC enzymes tested with highest potency in vitro observed toward recombinant HDAC1 (IC50, 0.11±0.03 nM), which is comparable with the potency observed toward HDAC1-immunoprecipitated complexes from tumor cells (IC50, 0.16±0.02 nM). Lowest in vitro potency is observed toward HDAC6, 7 and 9 (IC50, 32.1-119 nM) [1]. |
In vivo | JNJ-26481585 induces continuous H3 acetylation in tumor tissue in vivo. JNJ-26481585, a "second-generation" HDAC inhibitor with prolonged pharmacodynamic response in vivo. In agreement with the hypothesis, JNJ-26481585 showed superior efficacy compared with both standard of care agents and first-generation HDAC inhibitors in preClinicalal tumor models. These studies suggest that an HDAC inhibitor with continuous pharmacodynamic activity may show activity in solid tumor malignancies[1]. |
別名 | JNJ-26481585 |
分子量 | 394.47 |
分子式 | C21H26N6O2 |
CAS No. | 875320-29-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 79 mg/mL (200.26 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Quisinostat 875320-29-9 Apoptosis Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair HDAC deacetylase JNJ 26481585 inhibit hematologic Inhibitor Histone deacetylases histone JNJ26481585 JNJ-26481585 malignancies inhibitor