Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion.
説明 | AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion. |
In vitro |
AZA1 (Rac1/Cdc42-IN-1) (2-10 μM; 72 hours) impedes the proliferation of human 22Rv1 prostate cancer cells.[1] AZA1 (2-10 μM; 24 hours) diminishes phosphorylation of PAK1, AKT, and BAD in EGF-stimulated 22Rv1 prostate cancer cells.[1] AZA1 (10 μM; 24 hours) obstructs Rac1 and Cdc42-dependent cell cycle progression in 22Rv1 prostate cancer cells. AZA1 inhibits Rac1 and Cdc42-dependent migration of 22Rv1, DU 145, and PC-3 prostate cancer cells.[1] AZA1 influences cell motility and actin reorganization in prostate cancer cells by suppressing Rac1 and Cdc42 function through PAK1/2 phosphorylation.[1] |
In vivo | AZA1 (Rac1/Cdc42-IN-1) (100 μg; i.p.; daily for 2 weeks) is potent in suppressing human 22Rv1 xenograft growth in mice (5 week-old athymic nu/nu (nude)) and improving survival. The suppressive effect of AZA1 on tumor growth was significant.[1] |
別名 | Rac1/Cdc42-IN-1 |
分子量 | 368.43 |
分子式 | C22H20N6 |
CAS No. | 1071098-42-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (122.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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AZA1 1071098-42-4 Apoptosis Cell Cycle/Checkpoint Rho CDK Rac1/Cdc42-IN-1 AZA 1 AZA-1 Inhibitor inhibitor inhibit