Powder: -20°C for 3 years | In solvent: -80°C for 1 year
R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor.
説明 | R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor. |
In vitro | R162 decreased intracellular fumarate levels attenuated GPx activity by inhibited GDH1 activity, increased ROS levels, and reduced cell proliferation in H1299 and MDA-MB231 cells. R162 inhibits tumor growth potential and cell proliferation of human cancer cells. |
In vivo | In xenograft tumor mouse models, R162 (30 mg/kg/day, i.p.) does not cause a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties. Compared with control mice, R162 (20 mg/kg/day) markedly decreases tumor growth and masses and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice. |
分子量 | 264.28 |
分子式 | C17H12O3 |
CAS No. | 64302-87-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.85 mg/mL (14.55 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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R162 64302-87-0 Metabolism Dehydrogenase inhibit Inhibitor R 162 R-162 inhibitor