Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.
説明 | RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model. |
ターゲット&IC50 | RIPK1:(kd)4 nM , RIPK1:11 nM |
In vitro | In the TSZ-induced HT29 cell necroptosis model, RIPK1-IN-7 shows potent cell protection effect (EC50 of 2nM). RIPK1-IN-7 displays considerable activity against several other kinases(Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC50s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively). |
分子量 | 481.47 |
分子式 | C25H22F3N5O2 |
CAS No. | 2300982-44-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (124.62 mM), Sonication is recommended.
H2O: 0.1 mg/mL (insoluble)
You can also refer to dose conversion for different animals. 詳細
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RIPK1-IN-7 2300982-44-7 Apoptosis NF-Κb RIP kinase RIPK-1-IN-7 inhibit TrkA Mer Receptor-interacting protein kinases Flt4 Axl TrkB Inhibitor RIPK TrkC RIPK1 IN 7 RIPK1IN7 HRI inhibitor