Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infections.
説明 | Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infections. |
In vitro | Rilpivirine, dissolved in PEG 400 and administered via intravenous injection at dosages of 4 mg/kg in rats and 1.25 mg/kg in dogs, exhibits half-lives of 4.4 hours and 31 hours, respectively. |
In vivo | Rilpivirine demonstrates antiviral activity against both wild-type and selective point single and double HIV-1 mutants, with an effective concentration (EC50) ranging from 0.1 to 2 nM. |
別名 | TMC278, R278474, DB08864 |
分子量 | 366.42 |
分子式 | C22H18N6 |
CAS No. | 500287-72-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (150.1 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Rilpivirine 500287-72-9 Microbiology/Virology Proteases/Proteasome HIV Protease Reverse Transcriptase antiviral diarylpyrimidine DAPY transcriptase TMC-278 reverse TMC278 DB-08864 Inhibitor R278474 Human immunodeficiency virus mutant DB 08864 NNRTI wild-type non-nucleoside R 278474 inhibit R-278474 TMC 278 resistance DB08864 HIV inhibitor