store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 13,000 | |||
5 mg | 在庫あり | ¥ 33,500 | |||
10 mg | 在庫あり | ¥ 45,500 | |||
25 mg | 在庫あり | ¥ 99,000 | |||
50 mg | 在庫あり | ¥ 146,500 | |||
100 mg | 在庫あり | ¥ 204,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 44,500 |
説明 | Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM). |
ターゲット&IC50 | PLK1:3 nM |
In vitro | In nude mice implanted with HT-29 human colon tumors, RO3280 (40 mg/kg) was effective in inhibiting tumor cell proliferation. |
In vivo | RO3280 exhibits antitumor activity across a variety of tumor cell lines, effectively inhibiting cancer cell proliferation. Specifically, it demonstrates potency against lung cancer cell line H82 (IC50=5 nM), colorectal cancer cell HT-29 (IC50=10 nM), breast cancer cell MDA-MB-468 (IC50=19 nM), prostate cancer cell PC3 (IC50=12 nM), and skin cancer cell A375 (IC50=70 nM). |
別名 | RO 3280, Ro5203280 |
分子量 | 543.61 |
分子式 | C27H35F2N7O3 |
CAS No. | 1062243-51-9 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.2 mg/mL (50 mM)
Ethanol: 27.2 mg/mL (50 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Ro3280 1062243-51-9 Cell Cycle/Checkpoint PLK Inhibitor Polo-like Kinase (PLK) RO 3280 RO-3280 Ro5203280 inhibit Ro-3280 inhibitor