Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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2 mg | 在庫あり | ¥ 8,000 | |||
5 mg | 在庫あり | ¥ 13,000 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 44,500 | |||
50 mg | 在庫あり | ¥ 83,500 | |||
100 mg | 在庫あり | ¥ 143,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,500 |
説明 | ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. |
ターゲット&IC50 | PDGFR:18 nM(Cell-free assay) , FLK1:42 nM(Cell-free assay) , PLK1:9 nM(Cell-free assay) , BCR-ABL:32 nM(Cell-free assay) , Src:55 nM(Cell-free assay) |
In vitro | ON01910, a small molecule inhibitor of Plk1 activity, which induces mitotic arrest of tumor cells characterized by spindle abnormalities leading to their apoptosis.?This compound was not ATP-competitive, but competed for the substrate binding site of the enzyme[1]. |
In vivo | In vivo, this compound did not exhibit hematotoxicity, liver damage, or neurotoxicity, and was a potent inhibitor of tumor growth in a variety of xenograft nude mouse models.?ON01910 showed strong synergy with several chemotherapeutic agents, often inducing complete regression of tumors[1]. |
別名 | (E/Z) ON-01910 sodium |
分子量 | 473.47 |
分子式 | C21H24NNaO8S |
CAS No. | 1225497-78-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 94 mg/mL (198.53 mM)
You can also refer to dose conversion for different animals. 詳細
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(E/Z)-Rigosertib sodium 1225497-78-8 Cell Cycle/Checkpoint PLK ON01910 ON-01910 ON 01910 (E/Z) ON-01910 sodium Inhibitor inhibitor inhibit