Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 45,500 |
5 mg | 約 5 days | ¥ 76,500 |
25 mg | 約6-8 週間 | ¥ 226,500 |
50 mg | 約6-8 週間 | ¥ 312,500 |
100 mg | 約6-8 週間 | ¥ 457,000 |
説明 | S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity. |
ターゲット&IC50 | Tubulin polymerization:4.29 μM |
In vitro | S516 has potent cytotoxicity(HL-60, HCT116 and HCT15 cells with IC50s of 4.8 nM, 42.8 nM and 24.9 nM, respectively). S516 (30 nM; 16 hours; HL60 cells) treatmemt causes significant arrest of cells at the G2/M phase, resulting in apoptosis with concomitant loss of G0/G1 phase. |
In vivo | In human LX-1 lung cancer and CX-1 colon cancer mouse xenografts,S516 (5-10 mg/kg; intraperitoneal injection; mice) treatment has promising antitumor activity (inhibition ratio (IR)> 63%) . |
分子量 | 437.47 |
分子式 | C21H19N5O4S |
CAS No. | 1016543-77-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12.5 mg/mL (28.57 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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S516 1016543-77-3 Cytoskeletal Signaling Microtubule Associated S-516 S 516 Inhibitor inhibitor inhibit