Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).
説明 | SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8). |
ターゲット&IC50 | TRPV1:7.8(pKb) |
In vitro | SB 452533 significantly reduced Capsaicin-induced phosphorylation of AMPK and CAMKK2[1]. |
In vivo | Small dose Cap significantly reduced bleomycin-induced pulmonary fibrosis in mice and obviously reversed alveolar epithelial cells epithelial-mesenchymal transition (EMT) (the expression of E-cadherin and ZO-1 were increased(P<0.05 or P<0.01)and the expression of α-SMA and Vimentin were decreased (P<0.05 or P<0.01) after drugs treatment for 21 day, concomitantly with the increase the expressions of TRPV1 and CGRP (P<0.05 or P<0.01), and inhibiting ERK1/2 phosphorylation and eIF3a expression (P<0.05 or P<0.01). These effects of small dose Cap were abolished in the presence of TRPV1 receptor antagonist SB 452533[2]. |
分子量 | 376.29 |
分子式 | C18H22BrN3O |
CAS No. | 459429-39-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 50 mg/ml(132.876 mM)
You can also refer to dose conversion for different animals. 詳細
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SB 452533 459429-39-1 Membrane transporter/Ion channel TRP/TRPV Channel ATP glucose oxidation inhibit ERK1/2 TRPV1 pulmonary TRP Channel fibrosis CAMKK2 skeletal muscle capsaicin SB452533 Inhibitor SB-452533 Transient receptor potential channels inhibitor