Powder: -20°C for 3 years | In solvent: -80°C for 1 year
M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 8,000 | |||
5 mg | 在庫あり | ¥ 18,500 | |||
10 mg | 在庫あり | ¥ 26,000 | |||
25 mg | 在庫あり | ¥ 57,000 | |||
50 mg | 在庫あり | ¥ 91,500 | |||
100 mg | 在庫あり | ¥ 135,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 22,000 |
説明 | M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist. |
In vivo | M8 B, a TRPM8 antagonist, can reduce body temperature.M8 B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect.?It also induced a significant anticonvulsant effect in PTZ but not electroshock induced convulsions.?M8 B showed anticonvulsant effects in both febrile and PTZ induced seizures.?M8 B had a hypothermic effect with significant protective effects on febrile and PTZ induced seizures. |
動物実験 | Eight day old male Wistar rat pups were used for induction of febrile seizure.?M8 B and diazepam were injected intraperitoneally.?The rat pups were then transferred to a heated plexiglas chamber and the latency to the first febrile seizure was measured.?In addition, different groups of mice were pretreated with M8 B and received a convulsant dose of pentylenetetrazol (PTZ).?Latencies to stages 2 and 4 and duration of stage 5 seizure episodes were measured.The effect of M8 B on electroshock induced seizures was also investigated and hindlimb extension time was measured[1]. |
分子量 | 432.96 |
分子式 | C22H25ClN2O3S |
CAS No. | 883976-12-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (63.52 mM)
You can also refer to dose conversion for different animals. 詳細
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M8-B Hydrochloride 883976-12-3 Membrane transporter/Ion channel TRP/TRPV Channel M8 B Hydrochloride M-8-B Hydrochloride M8B Hydrochloride Inhibitor inhibitor inhibit