Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.
説明 | SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity. |
ターゲット&IC50 | LNCaPAR+ cells:0.2 μM |
In vitro | SK33 has a significantly potent activity (IC50:0.2 μM) in LNCaPAR+ cells. SK33 decreases cells enter S-phase in LNCaP cells. In LNCaP/BicR cells, increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth(IC50 : 5 μM for SK33). |
In vivo | AR transcriptional activity inhibited by SK33 after 50 mg/kg treatment for 24 hours. |
分子量 | 500.31 |
分子式 | C20H13F9N2O3 |
CAS No. | 1928724-23-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (109.93 mM)
You can also refer to dose conversion for different animals. 詳細
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SK33 1928724-23-5 Endocrinology/Hormones Androgen Receptor inhibit androgen PC3 cancer prostate SK 33 Inhibitor tissue LNCaP analogues cells SK-33 inhibitor