Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells via an mTOR-independent mechanism and prevented the accumulation of amyloid beta peptide.
説明 | SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells via an mTOR-independent mechanism and prevented the accumulation of amyloid beta peptide. |
In vitro | SMER28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. It increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. A marked decrease in Aβ/APP-CTF levels and enhancement for degradation of Aβ/APP-CTF via autophagy is also induced by SMER28. APP-CTF and LC3-II are cocompartmentalized on SMER28 treatment[1]. |
細胞研究 | MEF cells overexpressing βCTF are treated with autophagy-enhancing compounds (10 μM) for 16 h. Cell lysates are analyzed by SDS-PAGE and Western blotting using anti-βCTF (6E10) and anti-tubulin antibodies.(Only for Reference) |
分子量 | 264.12 |
分子式 | C11H10BrN3 |
CAS No. | 307538-42-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 26.4 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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SMER28 307538-42-7 Autophagy inhibit Inhibitor SMER-28 SMER 28 inhibitor